产褥期发热者C-反应蛋白变化的临床意义

Clinical significance of C-reactive protein changes in puerperal fever

目的探讨产褥期发热者C-反应蛋白(CRP)变化的临床意义。方法选取产褥期发热产妇96例作为A1组,选择同期分娩后无发热症状的正常产妇100例为A2组,比较两组产妇在分娩前以及分娩后48 h的CRP、白细胞介素-6(IL-6)以及WBC水平,并对A1组分娩后CRP水平与IL-6、WBC水平进行相关性分析。根据CRP水平将A1组产妇分为CRP>5 mg/L组以及CRP≤5 mg/L组,比较两组出现产褥感染发生率。结果分娩后A1组与A2组的CRP、IL-6及WBC水平均较分娩前升高(P<0.05),A1组高于A2组(P<0.05)。A1组分娩后的CRP水平与IL-6及WBC水平均呈正相关(P<0.05)。CRP>5 mg/L组的产褥感染率为16.67%,高于CRP≤5 mg/L组的1.85%(P<0.05)。结论对产褥期发热产妇进行CRP检测,有助于评估产妇是否合并产褥感染,从而可给予针性干预措施,提高产妇的生活质量。

Objective To explore the clinical significance of C-reactive protein（CRP） changes in puerperal fever. Methods A total of 96 delivery women with puerperal fever were enrolled as Group A1, and 100 concurrent normal delivery women without fever as Group A2. The levels of CRP, interleukin-6 （ IL-6 ） and WBC were compared between two groups before delivery and at 48 hours after delivery. The correlation of CRP level with IL-6 or WBC level after delivery was conducted in Group A1. The delivery women of Group A1 were divided into CRP 〉 5 mg/L group and CRP ≤5 mg/L group according to their CRP levels, and the incidences of puerperal infection were compared between these two groups. Results The levels of CRP, IL-6 and WBC of Group A1 and Group A2 after delivery were higher than the levels before delivery （P 〈 0.05 ）, and the levels of Group A1 were higher than those of Group A2 （P 〈 0.05 ）. The incidence of puerperal infection of CRP 〉5 mg/L group was 16.67%, which was higher than that of CRP ≤5 mg/L group（ 1.85% ）（P 〈 0.05）. Conclusion For delivery women with puerperal fever, CRP detection is helpful for the evaluation of puerperal infection, and then the targeted intervention should be performed in order to improve the quality of life of delivery women.