阿托伐他汀钙强化治疗对动脉粥样硬化脑梗死患者血脂水平及颈动脉斑块的影响

Effect of intensive treatment with atorvastatin calcium on blood lipid level and carotid artery plaque in patients with atherosclerotic cerebral infarction

目的探讨阿托伐他汀钙强化治疗对动脉粥样硬化脑梗死患者血脂水平及颈动脉斑块的影响。方法选择动脉粥样硬化脑梗死患者92例,以随机数字表法分为观察组和对照组各46例。两组均给予饮食控制,对照组采用常规剂量阿托伐他汀钙(10 mg/d)治疗,观察组采用强化阿托伐他汀钙(40 mg/d)治疗,观察治疗前后两组患者血脂情况以及颈动脉斑块情况。结果治疗后两组TC、TG、LDL-C水平、斑块大小、斑块厚度以及颈总动脉内膜-中层厚度(IMT)均低于治疗前(P<0.05),且观察组各项指标显著低于对照组(P<0.05);治疗后两组HDL-C水平升高(P<0.05),且观察组较对照组明显增高(P<0.05)。结论强化剂量阿托伐他汀可有效改善动脉粥样硬化脑梗死患者血脂异常和颈动脉斑块的情况。

Objective To explore the effect of intensive treatment with atorvastatin calcium on blood lipid level and carotid artery plaque in patients with atheroscierotic cerebral infarction. Methods A total of 92 patients with atherosclerotic cerebral infarction were enrolled and were divided into observation group （ n = 46 ） and control group （ n = 46 ） by random number table. The diet control was performed in both groups. And control group was administered atorvastatin calcium with normal dose（ 10 mg/d ） , while observation group received intensive treatment with atorvastatin calcium （40 mg/d）. The blood lipid level and carotid artery plaque were observed in both groups before and after treatment. Results After treatment, the levels of TC,TG and LDL-C were significantly lower, and the plaque size, plaque thickness and carotid artery intima-media thickness （IMT） were less in both groups （P 〈 0.05 ）, and those indicators in the observation group improved more significantly compared to the indicators in the control group（ P 〈 0.05 ）. The level of HLD-C increased in both groups after treatment（P 〈 0.05 ）, and the level in the observation group was significantly higher than that in the control group （P 〈 0.05 ）. Conclusion Atorvastafin calcium with intensive dose can improve effectively the abnormity of blood lipid and carotid artery plaque in patients with atherosclerotic cerebral infarction.