自体表皮移植术联合他克莫司软膏治疗白癜风22例临床观察

Clinical Observation on Autologous Epidermal Grafting with Tacrolimus Ointment Cream in the Treatment of 22 Patients with Vitiligo

目的探讨自体表皮移植术联合0.1%他克莫司软膏外用治疗稳定期白癜风的临床疗效和安全性。方法将入选的42例稳定期白癜风患者随机分为两组,自体表皮移植术组(对照组)20例,自体表皮移植术联合0.1%他克莫司软膏外用组(治疗组)22例,术后均随访6个月。结果两组患者均未见明显的不良反应,治疗组和对照组的有效率分别为79.63%和73.33%,差异有统计学意义(P<0.05),且治疗组色素再生更快、更均匀。结论自体表皮移植术联合0.1%他克莫司软膏外用治疗稳定期白癜风的临床疗效优于单纯自体表皮移植术的临床疗效,且两组患者的安全性均较好。

Objective To investigate the clinical efficacy and safety of autologous epidermal grafting in combination with topical 0. 1% tacrolimus ointment for stable vitiligo. Methods Forty-two patients with stable vitiligo were randomly divided into two groups,20 cases receiving autologous epidermal grafting alone（ control group） and 22 cases receiving both autologous epidermal grafting and topical 0. 1% tacrolimus ointment（treatment group）. Both groups were followed up for 6 months. Results The effective rate was significantly higher in treatment group than in controls（79. 63% vs. 73. 33%,P 〈0. 05）. Repigmentation was faster and more uniform in treatment than in controls. No adverse events were seen in either group. Conclusion Combination of autologous epidermal grafting and topical 0. 1% tacrolimus ointment is more effective than autologous epidermal grafting alone for stable vitiligo. Both regimens are safe for stable vitiligo.