滇南美登木中一个新三萜化合物

A New Triterpenoid from Maytenus austroyunnanensis

以抗肿瘤活性追踪法,利用多种分离手段,对滇南美登木中抗肿瘤活性成分进行了系统研究。结果发现三萜部分是主要活性部分,从中分离得到8个三萜类化合物,经波谱分析分别鉴定为:19α-羟基-3-氧代-12-烯-29-齐墩果酸(1)、22β-羟基-3-氧代-12-烯-29-齐墩果酸(2)、3β-羟基-22-氧代-12-烯-29-齐墩果酸(3)、3β-羟基-12-烯-29-齐墩果酸(4)、3β,22β-二羟基-12-烯-29-齐墩果酸(5)、3α,22α-二羟基-12-烯-29-齐墩果酸(6)、3β,22α-二羟基-12-烯-29-齐墩果酸(美登叶酸)(7)、3α,22β-二羟基-12-烯-29-齐墩果酸(8),其中化合物1为新化合物,化合物1、2、4、6对人宫颈癌He La肿瘤细胞系有显著的细胞毒活性。

In this study the method of anti-tumor activity tracking was used to screen active components from Maytenus austroyunnanensis. As a result, eight triterpenoids were isolated and identified respectively as ：19α-hydroxy-3-oxo-olean- 12-en-29-oic acid （ 1 ）, 22β-hydroxy-3-oxo-olean-12-en-29-oic acid （ 2 ）, 3β-hydroxy-22-oxo-olean-12-en-29-oic acid （3）, 3β-hydroxy-olean-12-en-29-oic acid （4）, 3β, 22β - dihydmxy-olean-12-en-29-oic acid （5）, 3 α, 22α-dihydroxyclean-12-en-29-oic acid （ 6）, 3/3,22 α-dihydroxy- olean-12-eu-29-oic acid （ maytenfolic acid ） （ 7 ）, 3 α, 22β-dihydroxyolean-12-en-29-oic acid （8） by means of spectroscopic methods. Compound 1 was a new compound. Compounds 1,2,4, 6 showed significant cytotoxic activity against HeLa cells.