无创呼吸机辅助尼克刹米治疗对AECOPD患者炎症因子的影响

Influence of non-invasive ventilator assisted treatment with nikethamide on inflammation factors of AECOPD patients

目的观察无创型呼吸机辅助尼克刹米治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效,并探讨其对炎症因子的影响。方法选择本科收治的AECOPD患者60例,按照配对分组法分为两组,每组30例。对照组给予尼克刹米+抗生素等常规治疗,观察组于对照组基础上应用无创型呼吸机治疗,比较两组疗效和治疗后血气指标及炎症因子的变化。结果观察组治疗有效率为90.0%,显著高于对照组(63.3%)(P<0.05)。治疗后观察组呼吸频率、心率和Pa CO2显著低于对照组,血氧饱和度Pa O2高于对照组(均P<0.05)。治疗后观察组IL-6、IL-1β、TNF-α均低于对照组(P<0.05)。结论无创型呼吸机辅助尼克刹米治疗AECOPD疗效较佳,且炎症反应程度降低,具有重要临床价值。

Objective To observe the curative effects of non-invasive ventilator assisted treatment with nikethamide on patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） during the acute exacerbation period, and to explore its influence on inflammatory factors. Methods 60 cases of AECOPD treated in the hospital were equally divided into two groups according to the paired grouping method. Control group was treated by routine treatment with nikethamide plus antibiotics, while observation group was treated by non-invasive ventilator based on the same therapy as the control group. Comparison was made in the curative effects and the changes of blood gas indexes and inflammatory factors after the treatment between the two groups, Results The effective rate of the observation group was 90.0% which was significantly higher than that of the control group （63.3%） （P 〈 0.05）. After the treatment, the respiratory rates, heart rates, and PaCO2 in the observation group were significantly lower than those in the control group, and the blood oxygen saturation and PaO2 were higher than those in the latter group （all P 〈 0.05）. After the treatment, the IL-6, IL-113, and TNF-α in the observation group were lower than those in the control group （P〈 0.05）.Conclusion The curative effects of non-invasive ventilator assisted treatment with nikethamide on AECOPD are good, and the degree of inflammation is decreased. The treatment has great clinical value.