克拉霉素联用硝呋太尔栓治疗非淋菌性宫颈炎疗效观察

Observation on curative effects of clarithromycin combined with nifuratel suppositories on non-gonococcal cervicitis

目的探讨克拉霉素联合硝呋太尔栓对非淋菌性宫颈炎的临床治疗效果。方法选取86例非淋菌性宫颈炎患者为研究对象,随机分为观察组和对照组各43例。观察组采用克拉霉素片联合硝呋太尔栓治疗,对照组采用克拉霉素片治疗,比较两组临床症状改善情况、疗效及炎症因子的变化。结果观察组治疗有效率明显高于对照组(90.70%vs.69.77%)(P<0.05);治疗后,观察组下腹坠胀不适、阴道分泌物多、泌尿系统感染等临床症状消失率明显高于对照组(P<0.05),TNF-α和IL-8水平明显低于对照组(P<0.05),病原体阳性转阴率均明显高于对照组(P<0.05)。结论克拉霉素联合硝呋太尔栓联合治疗非淋菌性宫颈炎,有利于抑制局部病原菌的增殖,改善患者临床症状及免疫功能,提高治疗效果。

Objective To discuss the curative effects of clarithromycin combined with nifuratel suppositories on non-gonococcal cervicitis, Methods cases of non-gonococcal cervicitis were selected as research objects and randomly and equally divided into observation group and control group. The observation group was given clarithromycin combined with nifuratel suppositories therapy, while the control group was given clarithromycin tablets. Comparison was made in the improvement of clinical symptoms, curative effects, and changes in inflammation factors between the two groups, Results The treatment effective rate of the observation group was significantly higher than that of the control group （90.70% vs. 69.77%）（P 〈 0.05）. After the treatment, the disappearance rate of clinical symptoms like ventral belly uncomfortable, more vaginal secretions, and urinary tract infection rate in the observation group was significantly higher than that in the control group （P 〈 0.05）. The levels of TNF-α and IL-8 in the observation group were significantly lower than those in the control group （P 〈 0.05）, and the rate of positive pathogen turning to negative in the former group was significantly higher than that in the latter one（P 〈 0.05）.Conclusion Clarithromyein combined with nifuratel suppositories for the treatment of non-gonococcal eervicitis can help to inhibit the local pathogenic bacteria proliferation, improve the clinical symptoms and immune function, and enhance the therapeutic effects.