运动训练抗失眠及对睡眠-觉醒周期调控的神经生物学机制

Effects and Neurobiological Mechanisms of Physical Exercise on Anti-insomnia and Regulating Sleep-wake Cycle

适度运动被证明抗失眠疗效显著,对睡眠-觉醒周期有积极调控作用,可在一定程度上替代镇静安眠类药物,且无副作用。尽管对失眠的运动疗法已有广泛关注,临床也有开展,但其神经生物学机制尚未完全明确,一般认为可能涉及中枢神经机制及生物钟效应、单胺类神经递质及其受体、相关细胞因子及肽类物质等在运动影响下的变化与调节。客观梳理现有的假说及机制,不仅能为运动抗失眠提供更完备的理论依据,也能明确现有机制研究的不足,展望未来的研究方向。

Moderate physical exercise has been proved to be as effective as Sedative-Hypnotic Drugs in treating insomnia and regulating sleep-wake cycle and without any side effects. Effects of exercise on insomnia have attracted attention and been used in clinical treatment, yet the underlying mechanism is still unclear. Based on the present study, the following factors are considered to explain the neurobiological mechanisms of exercise on insomnia： central neuro mechanisms and biological clock effect, monoamine neurotransmitter and their receptors, related cytokine and peptide substance. Analy- zing the present hypothesis and mechanisms can offer theoretical basis of exercise on insomnia and prospect the future re- search directions.