芪明颗粒对糖尿病患者脉络膜循环的影响

Effect of Qi Ming Granule on the choroidal circulation in diabetic patients

目的:探讨芪明颗粒对糖尿病患者眼部特别是视网膜及脉络膜血液循环的影响。方法:根据眼底造影结果将所有患者分为两组:无糖尿病视网膜病变组(no diabetic retinopathy,NDR)和非增殖型糖尿病视网膜病变组(nonproliferative diabetic retinopathy,NPDR),运用眼底血管造影检查评价糖尿病患者视网膜及脉络膜的血液循环状态及造影特征,重点观察服药前和服用芪明颗粒后的视网膜及脉络膜动脉的充盈时间,利用精确数据评价芪明颗粒对糖尿病患者眼部血液循环的影响。结果:在服用芪明颗粒3mo后NDR和NPDR两组糖尿病患者视网膜及脉络膜动脉充盈时间均加快,充盈倒置及脉络膜晚期斑点状强荧光的发生率明显下降。结论:芪明颗粒可以使视网膜及脉络膜的血流加快,改善糖尿病患者眼部血液循环状态,延缓糖尿病视网膜病变的发生和发展。

AIM：To investigate the effect of a Chinese medicine（Qi Ming granule） on the retinal and choroidal circulation in diabetes patients.·METHODS：According to the results of fundus fluorescein angiography（FFA）,all the 45 diabetes patients were divided into no diabetic retinopathy（NDR） group and nonproliferative diabetic retinopathy（NPDR） group.All subjects were examined by FFA and indocyanine green angiography（ICGA） at the same time.After taken Qi Ming granule for 3mo,all subjects were examined by the same method.FFA and ICGA were used to evaluate the retinal and choroidal circulation and their features.The key points were filling time for the retinal and choroidal circulation before and after treatments.The accuracy data was used to evaluate the effect.·RESULTS：After taken Qi Ming granule for 3mo,there were significant decrease of the retina and the choroid filling time in NDR and NPDR groups.The occurrence rate of various abnormal angiographic features were significantly decreased.·CONCLUSION：Qi Ming granule can accelerate the blood flow of retina and choroid,improve the blood circulation in diabetes patients,and delay the occurrence and development of diabetic retinopathy.