杞菊地黄丸辅助玻璃酸钠对干眼症患者视觉功能和泪膜稳定性的影响

Effect of Qijudihuang pill assisting sodium hyaluronate on visual function and tear film stability in patients with dry eye

目的：探讨杞菊地黄丸辅助玻璃酸钠对干眼症患者视觉功能和泪膜稳定性的影响。方法：选择2013-10/2015-07期间接受治疗的干眼症患者78例156眼为研究对象,根据入院时间随机分为观察组和对照组各39例78眼,观察组患者接受杞菊地黄丸联合玻璃酸钠治疗,对照组患者接受玻璃酸钠治疗。比较两组患者的视觉功能、泪膜稳定性、中西医临床积分及临床疗效。结果：临床疗效：观察组总有效率92%明显高于对照组74%（χ~2=4.532,P〈0.05）;视觉功能：观察组患者12c/d、18c/d、24c/d对应的对比敏感度明显高于对照组（P〈0.05）;泪膜稳定性：观察组患者的泪液分泌试验（SⅠt）和泪膜破裂时间（BUT）均明显高于对照组（P〈0.05）;中西医症状积分：观察组中医临床积分、西医临床积分均明显低于对照组（P〈0.05）。结论：杞菊地黄丸辅助玻璃酸钠能够改善视觉功能,提高泪膜稳定性,减轻中西医临床症状,提高治疗效果。

AIM：To study the effect of Qijudihuang pills assisting sodium hyaluronate on visual function and tear film stability in patients with dry eye.·METHODS：Seventy-eight patients（156 eyes） with dry eye from October 2013 to July 2015 were chosen for this study and randomly divided into observation group and control group,39 patients（78 eyes） in each group.The patients in observation group received Qijudihuang pills combined with sodium hyaluronate.The patients in control group received sodium hyaluronate only.The visual function,tear film stability,Chinese and Western medicine clinical integration and clinical curative effect were compared between the two groups.·RESULTS：Clinical curative effect：effective rate of observation group was 92%and was significantly higher than that of the control group as 74%（χ~2 = 4.532,P0.05）.Visual function：the contrast sensitivity of observation group at 12,18,24 c/d was significantly higher than those of the control group（P0.05）.Tear film stability：the Slt and BUT of observation group were significantly higher than those of the control group（P0.05）.Symptoms integral：Chinese medicine clinical integral and western medicine clinical integral of observation group were significantly lower than those of the control group（P0.05）.·CONCLUSION：Qijudihuang pills combined with sodium hyaluronate can improve visual function,tear film stability and Chinese and Western medical clinic symptoms,then improve the efficacy.