玻璃酸钠滴眼液治疗青少年近视患者配戴硬性透气性角膜接触镜相关性干眼

Therapeutic efficiency of sodium hyaluronate eye drops on dry eye in juvenile with myopia wearing rigid gas permeable contact lens

目的:观察1g/L玻璃酸钠滴眼液(不含防腐剂)对青少年近视患者配戴硬性透气性角膜接触镜(RGP)相关性干眼的疗效评价。方法:选择2015-01/05来我院门诊就诊的90例透气性角膜接触镜相关性干眼症近视患者,年龄12.75±4.15岁,屈光度-3.50±1.50D,患者均接受正规角膜塑形镜验配。将患者随机分为3组,每组30例60眼:A组使用RGP润滑液,4次/d,1滴/次;B组使用1g/L玻璃酸钠滴眼液(不含防腐剂),4次/d,1滴/次;C组在使用RGP润滑液(4次/d,1滴/次)后15min再用1g/L玻璃酸钠滴眼液(不含防腐剂)(4次/d,1滴/次)。观察各组患者用药前1d与用药后第1、2、4wk的眼部症状评分、Schirmer I试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光染色评分变化。结果:三组患者在用药1wk后的干眼症状、角膜荧光染色和BUT均较治疗前有明显的改善(P<O.05),三组患者的SⅠt值治疗前后差异均无统计学意义(P>0.05)。各组患者在治疗第2、4wk后和治疗1wk时测得的各项指标差异无统计学意义(P>0.05)。B组与A组对干眼症状、SⅠt和BUT的改善作用差异无统计学意义(P>0.05);B组较A组改善角膜荧光染色作用更明显,差异有统计学意义(P<0.05)。C组对改善干眼症状和角膜荧光染色作用优于A组(P<O.05)。C组对改善干眼症状上优于B组(P<0.05)。结论:1g/L玻璃酸钠滴眼液(不含防腐剂)能够稳定泪膜,促进角膜上皮损伤愈合,改善青少年近视患者配戴硬性透气性角膜接触镜所致干眼症状,具有一定的临床应用价值。

AIM：To investigate the therapeutic efficiency of preservative-free sodium hyaluronate eye drops on dry eye in juvenile myopia wearing rigid gas permeable contact lens（RGP）.·METHODS：Ninety cases with dry eye related to wearing RGP in juvenile with myopia from January to May 2015 were selected.The patients aged 12.75±4.15 years old,with diopter of-3.50±1.50 D as spherical equivalent and received normalized RGP.They were divided into 3groups randomly,each group of 30 cases（60 eyes）：group A used rewetting drops,1 drop each time,4 times per day;group B used preservative-free sodium hyaluronate eye drops（1g/L）,1 drop each time,4 times per day;group C used rewetting drops at first,then sodium hyaluronate eye drops was used 15 minutes later.All cases had been detected and evaluated by subjective symptoms of dry eye,Schirmer I test（SⅠt）,break-up time（BUT） and corneal fluorescent staining,at pre-therapy and 1,2,4wk of post-therapy.·RESULTS：The subjective symptoms of dry eye,corneal fluorescent staining and BUT of three groups had been obviously improved at 1wk after therapies than those before therapies（P0.05）.SⅠt of three groups hadn＇t shown significant differences after therapies（P0.05）.Every index of the three groups measured at 2 and 4wk after treatments had no significant differences compared to those measured at 1wk（P0.05）.There was no significant difference on subjective symptoms,SⅠt and BUT between group A and B（P0.05）,except on corneal fluorescent staining,on which group B was superior to group A and on which the difference was significant（P0.05）.Group C in improving the subjective symptoms of dry eye and corneal fluorescent staining was better than group A（P0.05）.Group C,on improving the subjective symptoms of dry eye,was better than group B（P0.05）.·CONCLUSION：Preservative- free sodium hyaluronate eye drops（1 g/L） can stabilize the tear film and promote the repair of corneal epithelial defects and significantly improve dry eye symptoms and signs in juvenile myopia wearing RGP,so it has certain clinical application value.