2型糖尿病患者血清唾液酸浓度与糖尿病性黄斑水肿的相关性

Study on correlation between level of serum sialic acid and diabetic macular edema in patients with type 2 diabetic

目的:探讨2型糖尿病患者血清唾液酸浓度与糖尿病性黄斑水肿的相关性。方法:选取65例2型糖尿病患者,以及54例正常对照,采取外周静脉血后用比色法测量血清唾液酸浓度。对于糖尿病患者采用视网膜血管荧光造影方法判断黄斑区水肿程度。结果:糖尿病患者65例中黄斑水肿22例,无黄斑水肿43例,其中1级水肿10例,2级水肿5例,3级水肿7例。糖尿病患者血清唾液酸浓度为96.56±14.29mmol/L,对照组的血清唾液酸浓度为42.44±17.68mmol/L,两组比较有显著统计学差异(P<0.05)。在糖尿病患者组,无黄斑水肿的患者血清唾液酸浓度为86.53±13.39mmol/L,有黄斑水肿的患者中血清唾液酸浓度为110.09±18.81mmol/L,两者差异具有统计学意义(P<0.05)。血清唾液酸浓度与黄斑水肿严重程度有显著正相关(r=0.62,P<0.05)。结论:血清唾液酸浓度在2型糖尿病患者并发黄斑水肿时明显升高,并且血清唾液酸浓度越高,黄斑水肿越严重。

AIM：To explore the correlation between the degree of diabetic macular edema（DME） and the level of serum sialic acid in patients with type 2 diacetic.·METHODS：Sixty-five patients with type 2 diabetes were included in this study and another 54 cases were included as health control group.The concentration of serum sialic acid was tested by colorimetric methed.The degree of DME was detected by fundus fluorescein angiography（FFA）.·RESULTS：In the 65 diabetes patients 22 cases had DME（level 1：10 cases,lebel 2：5 cases,lebel 3：7 cases）.The level of serum sialic acid in diabetic patients was 96.56±14.29mmol/L,that in control group was 42.44 ±17.68mmol/L,and the difference between the two groups was significant（P0.05）.In diabetes patients group,level of serum sialic acid was 86.53±13.39mmol/L in patients without DME and that was 110.09 ±18.81mmol/L in those with DME and the difference between the two groups was significant（P0.05）.Significant correlations existed between the level of serum sialic acid and DME（r=0.62,P0.05）.·CONCLUSION：The concentration of serum sialic acid increases in patients with DME,and the DME is severer as the level increasing.