同型半胱氨酸和超敏C反应蛋白在急性脑梗死中的临床意义

Clinical Significance of Homocysteine and Hypersensitive C-Reactive Protein in Acute Cerebral Infarction

目的探讨同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)在急性脑梗死病情监测中的应用价值。方法选取100例急性脑梗死患者作为观察组,100例健康体检者作为对照组,比较两组血清Hcy(应用免疫比浊法测定)及hs-CRP(应用荧光偏振免疫法测定)水平。同时根据不同脑梗死体积将观察组细分为小梗死组(35例)、中梗死组(35例)及大梗死组(30例),比较三组血清Hcy及hs-CRP水平,并分析脑梗死体积与血清Hcy及hs-CRP水平的相关性。结果观察组血清Hcy及hs-CRP水平均明显高于对照组;不同梗死体积患者的血清Hcy及hs-CRP水平存在显著差异;差异均具有统计学意义(P<0.05)。血清Hcy及hs-CRP水平与梗死体积均存在显著的正向直线相关性(P<0.05)。结论急性脑梗死患者血清Hcy及hsCRP水平显著升高,且与梗死体积有显著的相关性。血清Hcy及hs-CRP的检测可应用于监测急性脑梗死的病情。

Objective To investigate the application value of homocysteine（Hcy） and hypersensitive C-reactive protein（hs-CRP） in monitoring acute cerebral infarction（ACI）. Methods 100 ACI patients were set as observation group and 100 healthy subjects were set as control group, the levels of serum Hcy（detected by immunoturbidimetry） and hs-CRP（detected by FPIA） of two groups were compared.According to different infarct volume, the observation group was subdivided into small infarction group（35 cases）, middle infarction group（35 cases） and large infarction group（30 cases）. The levels of serum Hcy and hs-CRP of three groups were compared, the correlation between serum Hcy and hs-CRP levels and infarct volume was analyzed. Results The serum Hcy and hs-CRP levels of observation group were higher than those of control group（P〈0.05）; the serum Hcy and hs-CRP levels of patients with different infarct volume had significant difference（P〈0.05）. The serum Hcy and hs-CRP levels had positive linear correlation with infarct volume（P〈0.05）. Conclusions The serum Hcy and hs-CRP levels in patients with acute cerebral infarction increase significantly, and have obvious correlation with infarct volume. The detection of serum Hcy and hs-CRP can be used in monitoring the conditions of acute cerebral infarction.