奥卡西平治疗儿童部分性癫痫发作的临床疗效分析

Clinical Effects of Oxcarbazepine in Treatment of Children with Partial Epileptic Seizure

目的对奥卡西平医治儿童部分性癫痫发作的疗效与安全性进行分析。方法选取我院2010年1月至2014年12月收治的121例部分性癫痫发作患儿为研究对象,随机分为研究组(61例)与对照组(60例)。研究组仅给予奥卡西平治疗,对照组采用卡马西平治疗。比较两组的临床疗效和不良反应发生情况。结果研究组的不良反应发生率为8.20%,对照组的不良反应发生率为38.33%,组间差异具有统计学意义(P<0.05)。研究组的总有效率为96.72%,对照组的总有效率为83.33%,两组比较差异明显,具有统计学意义(P<0.05)。结论对部分性癫痫发作患儿实行单一奥卡西平医治,不良反应较少且临床效果明显,值得推广应用。

Objective To analyze the clinical effects and safety of oxcarbazepine in treatment of children with partial epileptic seizure. Methods 121 cases of children with partial epileptic seizure treated in our hospital from January 2010 to December 2014 were selected as research objects and divided into study group（61 cases） and control group（60 cases） according to the random number table. The study group was only given oxcarbazepine for treatment, the control group was treated with carbamazepine. The clinical effects and incidence of adverse reactions were compared between two groups. Results The incidence of adverse reactions of study group was 8.20%,significantly lower than 38.33% of control group, with statistically significant difference（P〈0.05）. The total effective rate of study group was96.72%, significantly higher than 83.33% of control group, with statistically significant difference（P〈0.05）. Conclusions Simple oxcarbazepine in treatment of children with partial epileptic seizure has significant effect and fewer adverse reactions, which is worthy of clinical promotion and application.