动静结合运动对阿霉素诱导的心衰大鼠心功能及血管紧张素Ⅱ和醛固酮水平的影响

The Influence of Static and Dynamic Movement on Cardiac Function,Angiotensin Ⅱ and Aldosterone Levels in Adriamycin-Induced Heart Failure Rats

目的:观察动静结合运动对阿霉素诱导的心衰大鼠的心功能及血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)水平的影响。方法:取清洁级雌、雄SD大鼠各30只,随机分成4组,空白组(n=15)予以正常喂养,不做任何处理;模型组(n=15)予以阿霉素造心衰大鼠模型,不进行心脏康复运动;对照组(n=15)予以阿霉素造心衰大鼠模型,进行力竭运动;实验组(n=15))予以阿霉素造心衰大鼠模型,进行动静结合运动。6周后测定心功能及AngⅡ和ALD水平。结果:实验组心功能明显优于对照组及模型组(P<0.05);实验组AngⅡ、ALD明显降低(P<0.05),表明动静结合运动有更明显效果。结论:动静结合运动可改善心衰大鼠的心功能,降低Ang II及ALD水平。

Objective： To investgate the influence of static and dynamic movement on cardiac function, angiotensin Ⅱ and aldosterone levels in Adriamycin-induced heart failure rats. Methods： The 30 clean female and male SD rats were divided into 4 groups at random. The rats were feed normal in blank group （n=15）, without any processing; the rats were made heart failure rat model with adriamycin in model group （n=15）, without cardiac rehabilitation exercise; the rats were were made heart failure rat model with adriamycin in control group （n=15）, with exhaustion exercise; the rats were were made heart failure rat model with adriamycin in experimental group （n=15）, with activity union movement. Angiotensin Ⅱ and aldosterone levels were determined in 6 weeks. Results： Experimental group showed better cardiac function than the control group and model group （P〈0.05）; the Ang Ⅱ and ALD were decreased in experimental group （P〈0.05）, which indicated activity union movement showed more obvious effect, Conclusion： Action combined with exercise can improve cardiac function and reduce AngⅡ and ALD levels in heart failure rats.