骨转换生化标志物的研究新进展

The research advance in bone turnover markers

骨转换生化标志物是在骨骼重建过程中释放于血液、尿液中的或其他分泌物,是能够被检测出来的一些活性物质,其具有稳定性好,特异性强,敏感性高等优点。虽然骨转换生化标志物不能作为诊断骨质疏松症的金标准,但是联合骨密度,我们可以更早地了解骨转换的动态,在骨转换平衡状态的评估、骨代谢疾病的鉴别诊断、抗骨质疏松治疗疗效监测等方面有重要作用。目前,一些传统的骨转换生化标志物(BALP、OC、PⅠNP、TRACP、DPD、CTX)已经成熟运用于临床和科研中,新发现的骨转换生化标志物(BSP、POSTN、SO、Cat K、OCIL等)在骨质疏松症和骨代谢疾病诊疗方面也有一定的应用,其灵敏性、特异性、稳定性仍需要进一步研究确认。本文从传统的骨转换生化标志物和新发现的骨转换生化标志物的研究进展及其在临床上的应用进行了简单的综述。

Bone turnover markers which have good stability, strong specificity, and high sensitivity, are active substances that are released in the blood, urine, or other secretions, and can be detected in the process of bone remodeling. Although bone turnover markers are not the gold standard in the diagnosis of osteoporosis, we can learn about dynamic bone transform earlier combined with bone mineral density （BMD）. Bone turnover markers play important roles in the evaluation of bone transformation balance, the differential diagnosis of bone metabolic diseases, and the monitoring of anti-osteoporosis treatment. So far, some traditional bone turnover markers, such as BALP, OC, PINP, TRACP, DPD, and CTX have been widely studied and applied in the clinical work and scientific research. The newly discovered bone turnover markers （BSP, POSTN, SO, Cat K, OCIL, etc） also have practical values for osteoporosis and bone metabolic disease, but their sensitivity, specificity, and stability still need further research to confirm. This paper reviews the aspect of clinical usage and research progress in the traditional bone turnover markers and newly discovered bone turnover markers.