加减柴胡承气汤联合生长抑素治疗青少年轻度急性胰腺炎31例临床观察

Clinical observation of 31 cases of mild acute pancreatitis in young patients treated with modified Chaihu Chengqi Tang and Somatostatin

目的探讨加减柴胡承气汤联合生长抑素治疗青少年轻度急性胰腺炎(MAP)的临床疗效。方法将62例MAP患儿随机分为对照组和治疗组,各31例。2组均采用常规治疗,对照组予注射用生长抑素250μg静脉注射,然后再将3 000μg注射用生长抑素溶于500 m L生理盐水中持续微量静脉泵泵注,泵速为250μg/h;治疗组在对照组治疗方法的基础上联合加减柴胡承气汤治疗,10 d为1个疗程。1个疗程后观察2组的临床疗效、实验室指标恢复时间以及住院时间等。结果对照组总有效率为70.97%,治疗组为96.77%,2组比较差异有高度统计意义(P<0.01);治疗后治疗组腹痛、腹胀消失,排气、饮食、血清淀粉酶恢复及住院时间明显短于对照组,2组比较差异有统计意义(P<0.05或P<0.01)。结论加减柴胡承气汤联合生长抑素治疗青少年MAP临床疗效显著,且不良反应小。

Objective To investigate the clinical effect of modified Chaihu Chengqi Tang and Somatostatin in the treatment of mild acute pancreatitis in young patients. Methods 62 children with mild acute pancreatitis were randomly divided into control group and treatment group with 31 cases in each group. 2 groups were all treated with conventional therapy. Control group was treated with Somatostatin. The treatment group was additionally treated with modified Chaihu Chengqi Tang on the basis of control group. After 10 days treatment, statistics was made in the clinical efficacy, the recovery time of laboratory index and the possible time of hospital stay. Results The total ef- fective rate was 70.97% for the control group,96.77% for the treatment group, the difference between the 2 groups was statistically significant （P〈0.01） ;the treatment group was significantly shorter than the control group in abdominal pain, abdominal distension, exhaust, diet, serum amylase recovery and hospitalization time, the difference between the 2 groups was statistically significant （ P 〈 0.05 or P 〈 0.01 ）. Conclusion The clinical efficacy of Somatostatin and modified Chaihu Chengqi Tang was obvious in treating mild acute pancreatitis, with little adverse reactions.