大株红景天联合磷酸肌酸钠治疗不稳定型心绞痛疗效观察

Clinical analysis of the efficacy of creatine phosphate sodium combined with rhodiola injection for the treatment of unstable angina pectoris

目的观察大株红景天联合磷酸肌酸钠治疗不稳定型心绞痛(UAP)的临床疗效。方法选取自2014年1月至2014年12月南京军区福州总医院收治的冠心病不稳定型心绞痛患者123例,将其随机分为治疗组和对照组。治疗组与对照组均进行常规治疗。在常规治疗基础上,对照组患者使用磷酸肌酸钠治疗;而治疗组在对照组基础上使用大株红景天注射液静脉滴注,连续治疗10 d。观察两组患者临床疗效,分析两组患者血液流变学、甘油三酯、胆固醇、血浆IL-6和hs-CRP水平变化。结果治疗后,两组患者临床症状均明显缓解,客观检验学指标改善。与治疗前比较,治疗组患者在心肌缺血疗效和心电图改变方面,明显改善(P<0.05);血流变学、血脂、IL-6、CRP等指标明显下降(P<0.05)。而且与对照组比较,治疗组患者的治疗效果更加显著(P<0.05)。结论大株红景天联合磷酸肌酸钠较单独采用磷酸肌酸钠治疗冠心病不稳定型心绞痛疗效更为显著,且无明显不良反应,安全性高,值得临床推广。

Objective To explore the clinical effect of creatine phosphate sodium combined with rhodiola injection for the treatment of unstable angina pectoris （ UAP） . Methods A total of 123 patients diagnosed as UAP received in our hospital from January 2014 to December 2014 were enrolled in this study. All cases were divided into soften group and control group, and conventional therapy was per-formed in both groups. Based on the routine treatment, patients in the control group were treated with creatine phosphate sodium, While, patients in the soften group with rhodiola injection for a consecutive 10 days. Clinical effect and serum levels were observed. Results All cases in both groups got satisfied outcome after treatment with improved clinical laboratory examinations. Situation of myocardial ischemia and ECM had improved significantly when compared to pre-treatment （ P〈0. 05 ） , and levels of hemorheology, lipid, IL-6 and CPR were reduced （P〈0. 05）. Patients in the soften group received better effects when compared with the control （P〈0. 05）. Conclusion It could obtain better clinical effects via the combined application of creatine phosphate sodium combined with rhodiola injection for the treatment of UAP, when compared with simplex using of creatine phosphate sodium, and it is worth spreading in clinic.