腹膜透析联合醒脑静注射液治疗尿毒症脑病临床观察

Clinical observation of peritoneal dialysis combined with Xingnaojing injection on the treatment of uremic encephalopathy

目的观察醒脑静注射液联合腹膜透析治疗尿毒症脑病的疗效。方法将30例尿毒症脑病患者随机分为治疗组和对照组,每组各15人。两组患者均给予基础治疗及腹膜透析治疗,治疗组加用醒脑静注射液。观察治疗前、后临床疗效、肾功能、全段甲状旁腺激素(iPTH)、β2-微球蛋白(β2-MG)等。结果治疗组患者在治疗过程中未发生明显不良反应。治疗组总有效率(87%)优于对照组(73%),两组间比较差异有统计学意义(P<0.05)。两组患者治疗前、后的血肌酐、尿素、iPTH、β2-MG变化,差异均无无统计学意义(P>0.05)。结论腹膜透析联合醒脑静注射液治疗尿毒症脑病可有效改善临床症状,显效快,提高了抢救成功率,是治疗尿毒症脑病安全、有效的方法。

Objective To eva1uate the effect of combination of peritonea1 dia1ysis and xingnaojing injection on uremic encepha1opa-thy. Methods A tota1 of 30 patients with end-stage rena1 disease were divided into the treatment group and the contro1 group. Each group inc1uded 15 patients. Basic treatment and peritonea1 dia1ysis treatment were admitted to a11 patients of both groups. Patients in the treatment group were treated with Xingnaojing injection. The c1inica1 curative effect,rena1 function,iPTH（parathyroid hormone）,β2-MG（β2microg1obu1in）were observed before and after treatment. Results There is no adverse reactions during treatment in the treat-ment group. The tota1 effective rate of treatment group was better than that of the contro1 group（87% versus 73% ,P 〈 0. 05）. Before and after the treatment,the serum creatinine,urea,Ipth,2-MG had no significant changes between the treatment group and the contro1 group. Conclusion Peritonea1 dia1ysis combined with Xingnaojing injection can effective1y and quick1y improve the c1inica1 symptoms and the success rate of rescue,and it can be a safe and effective method for the treatment of uremic encepha1opathy.