头孢呋辛与阿奇霉素联合应用对哮喘患儿MP抗体及嗜酸性粒细胞影响

The influence of Cefuroxime combined with azithromycin for pediatric asthma MP antibody positive and eosinophils

目的探讨头孢呋辛联合阿奇霉素对哮喘患儿MP抗体及嗜酸性粒细胞(EG)的影响。方法选择2012年4月至2013年4月在我院接受治疗的80例哮喘患儿作为研究对象(哮喘组)。以随机数字法将80例患儿分成联合治疗组(40例)和头孢呋辛组(40例)。另取同期来我院进行健康体检的健康儿童80例作为对照组。对哮喘组患儿进行治疗,其中,头孢呋辛组采用单纯的头孢呋辛钠治疗,联合治疗组使用头孢呋辛及阿奇霉素治疗。统计并对比哮喘组和对照组的MP抗体阳性、EG计数水平,治疗后MP抗体阳性情况,以及治疗后EG计数及症状缓解的时间。结果哮喘组MP抗体阳性和EG升高的比例,且MP抗体阳性的滴度和EG计数水平均显著高于对照组,差异均有统计学意义(P<0.05)。联合治疗组的MP抗体阳性率为5.00%(2/40),显著低于头孢呋辛组的20.00%(8/40),差异有统计学意义(P<0.05)。联合治疗组的EG计数及症状缓解的时间均显著少于对照组,差异有统计学意义(P<0.05)。结论头孢呋辛及阿奇霉素联用治疗小儿哮喘的疗效较好,有积极的临床意义。

Objective To exp1ore the inf1uence of Cefuroxime combined with azithromycin for pediatric asthma MP antibody positive and eosinophi1s. Methods From Apri1 2012 to Apri1 2013,80 cases of pediatric asthma patients were received in our hospita1 for treatment as the research object（asthma group）. By the method of digita1 joint random1y divided into treatment group（40 cases）and cefuroxime group（40 cases）. At the same period in the hospita1 for physica1 examination of 80 cases of hea1thy chi1dren were enro11ed as contro1 group. The asthma group was treated with using simp1e cefuroxime sodium therapy;the combination treatment group was trea-ted with cefuroxime and azithromycin. It did statistics and contrast of asthma group and the contro1 group of MP antibody positive and EG counting,MP antibody positive patients after treatment,and treatment of patients after EG counting and the time of symptoms. Re-sults Asthma group′s MP antibody positive and EG rising proportion,and the drop degree of MP antibody positive and EG counting 1eve1s were significant1y higher than the contro1 group,and differences were statistica11y significant（P 〈 0. 05）. Combination group′s MP antibody positive rate was 5. 00%（2 / 40）,which was significant1y 1ower than cefuroxime group′s 20. 00%（8 / 40）. Combination group of EG counting time and symptoms were significant1y 1ess than the contro1 group,differences were statistica11y significant（P 〈0. 05）. Conclusion Cefuroxime and azithromycin combination treatment the curative effect of chi1dhood asthma is better,worthy of c1inica1 recommendations.