紫杉醇脂质体联合复方苦参注射液治疗恶性腹腔积液疗效及安全性分析

United Fufangkushen paclitaxel liposome injection in the treatment of malignant ascites efficacy and safety analysis

目的探究紫杉醇脂质体联合复方苦参注射液治疗恶性腹腔积液的疗效性及安全性。方法选取我科80例恶性肿瘤伴有腹腔积液患者,采用随机数字表法将所有患者平均分成5组,每组16例,向A组腹腔内注射紫杉醇脂质体30 mg,复方苦参注射液30 ml;向B组腹腔内注射紫杉醇脂质体60 mg,复方苦参注射液30 ml;向C组腹腔内注射紫杉醇脂质体30 mg;向D组腹腔内注射紫杉醇脂质体60 mg;向E组腹腔内注射顺铂40 mg;每周期注药前行超声探查腹腔积液量,监测腹腔积液量的变化及临床症状的改变。结果 (1)B组临床治疗总有效率明显高于A和E组(P<0.05);(2)D组临床治疗总有效率明显高于C组(P<0.05);(3)A组恶心呕吐、发热发生率明显低于C组,且血小板降低发生率明显低于B组(P<0.05);(4)B组恶心呕吐发生率明显低于E组,发热发生率明显低于D组(P<0.05);(5)B组患者腹胀,气短、呼吸困难等症状缓解最为显著。结论紫杉醇脂质体联合复方苦参注射液能够有效抑制腹腔积液的生成,降低化疗药物毒副反应,提高患者生活质量,效果显著,且安全性较高,值得临床广泛推广。

Objective To exp1ore pac1itaxe1 1iposome combined Fufangkushen injection in treatment of ma1ignant ascites efficacy and safety. Methods Tota11y 80 cases of patients with ma1ignant ascites,using random number tab1e a11 the patients were divided into five groups,16 cases in each group,into the A group were injected with 1iposoma1 pac1itaxe1 30 mg,Fufangkushen injection 1iquid 30m1;in-traperitonea1 injection into the group B 1iposoma1 pac1itaxe1 60mg,compound Fufangkushen Injection 30 m1;group C injected into the 1iposoma1 pac1itaxe1 30 mg;D group was injected into the 1iposoma1 pac1itaxe1 60mg;the E group were former week1y injection of ascites vo1ume u1trasound probe to monitor changes in the amount of ascites and symptoms of change;injection of cisp1atin 40 mg. Results （1）Group B c1inica1 tota1 effective rate was significant1y higher than A and E group（P 〈 0. 05）;（2）C1inica1 tota1 effective D group was obvious1y higher than that of group C（P 〈 0. 05）;（3）A group of nausea and vomiting,fever incidence was significant1y 1ower in group C,and thrombocytopenia were significant1y 1ower than group B（P 〈 0. 05）;（4）Group B was 1ower than that in group E inci-dence of nausea and vomiting,fever incidence was 1ower than that in group D（P 〈 0. 05）;（5）Abdomina1 distension,group B patients symptoms such as shortness of breath,difficu1ty breathing is most significant1y. Conclusion Pac1itaxe1 1iposome unite Fufangkushen injection can effective1y inhibit the generation of ascites,reduce chemotherapy toxicity,improve qua1ity of 1ife of patients. The method is simp1e,the effect is significant,and high security,is worthy of wider promotion.