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辛伐他汀联合依折麦布治疗家族性高胆固醇血症疗效评价 被引量:1

The Curative Effect of Simvastatin with or without Ezetimibe in Familial Hyper-Cholesterolemia
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摘要 1文献来源Kastelein JJ,Akdim F,Stroes ES,et al.Simvastatin with or without Ezetimibe in familialhypercholesterolemia[J].N Engl J Med,2008,358(14):1431-1443.2证据水平1b。3背景低密度脂蛋白胆固醇(low density lipoproten-cholesterol,LDL-C)降低是心血管疾病预防的最重要的措施之一。
作者 钱孝贤 王敏
出处 《循证医学》 CSCD 2015年第6期339-341,347,共4页 The Journal of Evidence-Based Medicine
关键词 家族性高胆固醇血症 依折麦布 辛伐他汀 familial hypercholesterolemia Ezetimibe Simvastatin
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参考文献8

  • 1Ballantyne CM, Houri J, Notarbartolo A, et al. Effect of Ezetimibe eoadministered with Atorvastatin in 628 patients with primary hypercholesterolemia a prospective, randomized, double- blind trial[J]. Circulation, 2003,107(19) :2409- 2415.
  • 2Smilde TJ, van Wissen S, Wollersheim H, et al. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP) : A prospective, randomized, double-blind trial[J]. Lancet, 2001, 357(9256) :577-581.
  • 3Landmesser U, Bahlmann F, Mueller M, et al. Simvastatinversus Ezetimibe: Pleiotropic and lipid- lowering effects on endothelial function in humans [ J ]. Circulation, 2005, 111 (18) : 2356-2363.
  • 4Fichtlscherer, Schmidt-Lucke C, Bojunga S, et al. Differential effects of short-term lipid lowering with Ezetimibe and statins on endothelial function in patients with CAD: Clinical evidence for pleiotropic functions of statin therapy[J]. Eur Heart J, 2006, 27 (10) : 1182-1190.
  • 5Robinson JG, Smith B, Maheshwari N, et al. Pleiotropic effects of statins: Benefit beyond cholesterol reduction? A meta- regression analysis[J]. J Am Coil Cardiol, 2005, 46(10) : 1855- 1862.
  • 6Fleg JL, Mete M, Howard BV, et al. Effect of statins alone versus statins plus Ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial[J]. J Am Coll Cardiol, 2008, 52(25) :2198-2205.
  • 7Holme I, Boman K, Brudi P, et al. Observed and predicted reduction of ischemic cardiovascular events in the Simvastatin and Ezetimibe in aortic stenosis trial [J]. Am J Cardiol, 2010, 105(12) : 1802-1808.
  • 8Spinar J, pinarov6 L, Vftovec J. Improved reduction of outcomes: Vytorin efficacy international trial [J]. Vnitr Lek, 2014, 60(12) : 1095-1101.

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