黄芪注射液治疗急性心肌梗死PCI术后临床疗效观察

Clinical Observation on Astragalus Injection for Treatment of Acute Myocardial Infarction after Percutaneous Coronary Intervention

目的黄芪注射液对急性心肌梗死(AMI)经皮冠脉介入术(PCI)术后患者临床症状、心功能及相关指标的影响。方法将40例急性心肌梗死PCI术后患者随机分两组,黄芪组(20例)与对照组(20例),对照组予常规治疗方法,包括抗栓、扩冠、调脂、抗心肌缺血等;黄芪组在常规治疗基础上给予黄芪注射液静滴治疗,每日1次,疗程为12 d±2 d。比较两组间治疗前后症状体征、心功能(Killip分级)及血浆一氧化氮(NO)、内皮素(ET)、超氧化物歧化酶(SOD)值的变化。结果两组经积极药物治疗后,病情均有明显好转,黄芪组总有效率明显优于对照组(P<0.05);与对照组相比,黄芪组在症状量化评分优化与心功能分级改善上有统计学意义;黄芪组治疗后,NO,SOD值明显升高,ET值明显降低,改善均有统计学意义(P<0.05),对照组治疗后NO,SOD,ET较治疗前无明显改善;组间比较NO无统计学意义(P>0.05);SOD,ET有统计学意义(P<0.05)。结论黄芪注射液可有效改善AMI患者PCI术后胸闷等心肌缺血的临床症状,改善心功能,对长期预后起着有益的作用。

Objective Astragalus injection was used in patients with acute myocardial infarction （AMI） received by percutaneous core nary intervention（PCI）.The changes of clinical symptoms, Killip class and relative markers to verify the efficacy were observed. Methods Forty patients with AMI received by PCI were randomly divided into two groups： Control group（n = 20） treated with rou- tine treatment, including anti- thrombus,coronary dilatation, lipid regulation, anti - myocardial ischemia, and treatment group（ n = 20）treated with routine treatment along with astragalus injection, once a day,for 12＋ 2 days.The change of symptoms, Killip class and the ~evels of serum nitric oxide （NO） ,endothetin （ET）, superoxide dismutase （SOD） were observed and compared. Results During positive treatments, patients in both groups were alleviated, especially in treatment group.There was statistical significance between two groups（ P = 0.032〈0.05）.There was statistical significance in the symptoms quantitative score and Killip class between two groups（ P 〈0.05 or P 〈0.01）. The levels of serum NO and SOD in treatment group were up - regulated while ET levels was down- regulated,there was statistical significance（ P 〈0.05）.NO, SOD level in control group had no improvement（ P 〉0.05）.Com parison of NO among groups had no statistical significance（ P 〉0.05） ,while there was statistical significance in NO, SOD level （ P 〈0.05）. Conclusion Astragalus injection can alleviate the symptoms,improve the cardiac function,prognosis,vascular endothelial function, and enhance cell oxidative stress ability.