祛痰化瘀法对颈动脉内-中膜厚度及肱-踝脉搏波速的影响

Influence of Eliminating Phlegm and Removing Blood-stasis Therapy on Carotid Intima-media Thickness and Brachial-ankle Pulse Wave Velocity

目的观察祛痰化瘀法对颈动脉内-中膜厚度(IMT)及肱-踝脉搏波速度(baPWV)干预的临床疗效。方法将60例动脉粥样硬化临床前期病变患者随机分为两组,药物组30例,给予祛痰化瘀法治疗;对照组30例,给予安慰剂治疗。观察1年时间。结果药物组和对照组相比,药物组的颈动脉内-中膜厚度有显著改善(P<0.01)。药物组肱-踝脉搏波速度(baPWV)显著降低(P<0.01),药物组baPWV低于对照组(P<0.05)。结论祛痰化瘀法可以显著改善动脉粥样硬化临床前期病变患者的动脉结构和功能,以祛痰化瘀法治疗动脉粥样硬化临床前期病变具有显著的疗效。

Objective To investigate the effect of eliminating phlegm and removing blood - stasis therapy on carotid intima - mediathickness and brachial - ankle pulse wave velocity（baPWV）. Methods Sixty patients with preclinical atherosclerosis were randomly divided into two groups：The control group（ n = 30） treated with placebo, and the treatment group（ n = 30）treated with eliminating phlegm and removing blood - stasis therapy for one year. Results The carotid intima - media thickness （IMT） were improved in treatment group,which was better than that in control group（ P ~ 0. 01）. The baPWV in treatment group were reduced, which was lower than that in control group（ P 〈0. 051. Conclusion The eliminating phlegm and removing blood - stasis therapy can improve the artery＇s structure and function in patients with PCA. It has notable curative effect on preclinical atherosclerosis.