地尔硫卓与阿司匹林联合治疗心绞痛的临床疗效观察

Clinical therapeutic effect of aspirin combined with diltiazem on angina pectoris

目的观察地尔硫卓联合阿司匹林治疗心绞痛的临床疗效。方法回顾性分析我院2013年1月至2015年5月治疗的80例心绞痛患者的临床资料,分为阿司匹林组(常规治疗基础上仅给予阿司匹林)和联合用药组(常规治疗基础上给予阿司匹林和地尔硫卓联合治疗)。观察并比较两组患者治疗前后心绞痛的发作频率、持续时间和临床治疗效果的差异。结果治疗后联合用药组心绞痛症状改善总有效率高于阿司匹林组(90.0%:70.0%),差异有统计学意义(P<0.05)。治疗后联合用药组心电图总有效率为96.0%,高于阿司匹林组的80.0%,,差异有统计学意义(P<0.05)。联合用药组心绞痛频率、硝酸甘油用量、心电图缺血次数和心电图缺血时间均少于阿司匹林组,差异均有统计学意义(P<0.05)。结论阿司匹林与地尔硫卓联合治疗心绞痛的治疗方式比单用阿司匹林的治疗方式疗效更为明显,该种联合治疗心绞痛的方式是目前较为安全有效的治疗方式,具临床可实施性。

Objective To explore the therapeutic effect of aspirin combined diltiazem on angina pectoris. Methods A total of 80 pa-tients hospitalized in our hospital were enrolled in this study,and they were randomly and equally divided into combined medication group（ patients received combined therapy of aspirin and diltiazem based on routine treatment） and aspirin group（ patients only received aspirin based on routine treatment）. Attack frequency,duration of angina pectoris and clinical therapeutic effect were observed and compared between the two groups before and after treatment. Results Clinical efficacy in combination group was much higher than that in aspirin group（90. 0% versus 70. 0%）,and the difference was statistically significant（P〈0. 05）. The electrocardiogram cura-tive effect total effective rate（96. 0%）of the combination group was obviously better than 80. 0% of the aspirin group,and the differ-ence was statistically significant（P〈0. 05）. The angina attack frequency,the amount of nitroglycerin,ECG ischemia times and ECG ischemia time in combination group were better compared with that in aspirin group,and the difference was statistically significant（ P〈0. 05）. Conclusion Combined therapy of aspirin and diltiazem possesses more significant therapeutic effect on patients with angina pectoris,and it is safe for application in clinic.