聚合物纳米空心微球的制备及药物缓释性能研究

Preparation of Polymer Hollow Microsphere and Its Drug Release Property Study

以二乙烯三胺和甲苯-2,4-二异氰酸酯为基本原料,在室温下通过反相细乳液界面聚合法制备了聚脲空心微球。研究了乳化剂、连续相、分散相和助稳定剂对反相细乳液稳定性和空心微球形貌的影响,并通过透射电子显微镜和红外光谱对其形貌和结构进行了分析。研究表明,当以司盘80为表面活性剂、甲酰胺为分散相、环己烷为连续相、Ag NO3为助稳定剂时,可制备出粒径在100 nm左右且具有明显空心结构的聚脲纳米微球,其微球囊壁厚度约为1 7 n m。以罗丹明B为模拟药物对纳米空心微球进行了药物装载及体外释放研究,研究结果表明空心微球具有较强的药物负载能力和良好的药物缓释性能,每克空心微球最大药物吸附量可达101 mg罗丹明B(即101 mg/g),体外连续释药时间能达14 h以上。

Using diethylenetriamine and 2,4-tolylene diisocyanate as basic reactive materials, hollow polyurea microspheres were synthesized via interfacial polycondensation in inverse miniemulsion at room temperature. The effects of emulsifier, continuous phase, dispersed phase and stabilizer on the stability of inverse miniemulsion and morphology of the hollow microspheres were investigated. The morphology and structure were characterized by transmission electron microscopy and fourier transform infrared spectroscopy. Research shows that the polyurea hollow microspheres are synthesized with Span80 as the surfactant, formamide as the dispersed phase, cyclohexane as continuous phase and AgNO3 as the stabilizer. The size and wall thickness of hollow microspheres are about 100 nm and 17 nm respectively. The drug loading and release properties of nano hollow microspheres were investigated with Rhodamine B as a model drug. The results show that the maximum adsorptive capacity reaches 101 mg Rhodamine B per 1.00 g of the hollow microspheres （101 mg/g） and its release time reaches 14 h or more.