左卡尼汀联合血液透析治疗尿毒症性周围神经病变38例疗效分析

Clinical effect of L-carnitine combined with hemodialysis in the treatment of uremic peripheral neuropathy in 38 cases

目的:观察左卡尼汀与血液透析(HD)联合治疗尿毒症性周围神经病变的临床疗效。方法:76例尿毒症性周围神经病变患者,根据随机数字表法分为对照组和观察组,各38例。对照组采用普通HD治疗,观察组在对照组相同HD方案基础上联用左卡尼汀治疗,比较2组患者的治疗效果与神经传导速度变化情况。结果:观察组治疗后感觉神经传导速度较治疗前显著提高(P<0.01),且观察组治疗后水平显著高于对照组(P<0.01)。观察组总有效率为86.8%,显著高于对照组的57.9%(P<0.01)。结论:左卡尼汀联合HD可显著改善尿毒症患者周围神经病变症状,方法简单,疗效可靠。

Objective ：To observe the clinical efficacy of L-carnitine combined with hemodialysis in the treatment of uremic peripheral neuropathy. Methods： Seventy-six patients with uremic peripheral neuropathy were randomly divided into the control group and observation group （38 cases each group）. The control group and observation group were treated with ordinary hemodialysis and L- earnitine combined with hemodialysis, respectively. The curative efficacy and nerve conduction velocity between two groups were compared. Results：Compared with before treatment, the sensory nerve conduction velocity in observation group significantly increased （ P 〈 0.01 ）, and the level of which was significantly higher than that in control group after treatment（ P 〈 0.01 ）. The total effective rate in observation group（86.8% ） was significantly higher than that in control group（57.9% ） （P 〈 0.01 ）. Conclnsions ：The treatment of uremic patients with peripheral neuropathy with L-carnitine combined with hemodialysis can significantly improve the symptom of patients, which is effective and simple.