氧化还原反应与男性2型糖尿病合并勃起功能障碍的关系研究

The relationship between the redox reaction and male patients with type 2 diabetes erectile dysfunction

目的:探讨氧化还原反应与男性2型糖尿病合并勃起功能障碍(type 2 diabetes erectile dysfunction,DED)的关系,为DED患者的诊断与治疗提供新的思路。方法:选择60例中老年男性作为参试人群,对照组、2型糖尿病无勃起功能障碍组(NED组)和DED组各20例。检测血清中过氧化反应产物4-羟基壬烯酸、血清丙二醛(MDA)以及一氧化氮(NO)含量的表达,初步判断DED与氧化还原反应之间的关系。结果:DED组体质量指数与糖化血红蛋白均明显高于NED组和对照组(P<0.01);NED组糖化血红蛋白显著高于对照组(P<0.01);DED组血清总睾酮值与国际勃起功能障碍-5评分均显著低于NED和对照组(P<0.01);NED组血清总睾酮值亦明显低于对照组(P<0.01)。DED组中4-羟基壬烯酸和血清MDA值均明显高于NED组及对照组(P<0.01);且NED组血清MDA亦明显高于对照组(P<0.05);DED组血清NO含量均明显低于NED组及对照组(P<0.01),而NED组血清NO含量亦显著低于对照组(P<0.01)。结论:氧化还原反应可能通过NO介导的阴茎血管内皮损伤对DED的发生、发展起到促进作用。

Objective：To explore relationship between the redox reaction and male patients with type 2 diabetes erectile dysfunction （DED） to provide the new reference in the diagnosis and treatment of DED. Methods：Sixty middle-aged men were divided into the control group, type 2 diabetes non-erectile dysfunction （ NED group ） and type 2 diabetes erectile dysfunction group （ DED group） （ 20 cases each group）. The serum levels of peroxidation product 4-hydroxynonenal （ 4-HNE）, Malonaldehyde （MDA） and Nitric oxide （NO） were detected,the relationship between peroxidation and DED was identified. Results：The body mass index （BMI） and Glyeated hemoglobin（ HbA1 c） in DED group were significantly higher than those in NED group and control group（P 〈 0.01 ） ,the HbA1 c level in NED group was significantly higher than that in control group （ P 〈 0.01 ）. The total testosterone and IIEF-5 in DED group were significantly less than those in NED group and control group（ P 〈 0.01 ） , the total testosterone level in NED group was significantly less than that in control group（ P 〈 0.01 ）. The serum levels of 4-HNE and MDA in DED group were significantly higher than those in NED group and control group（ P 〈 0.01 ） ,the MDA level in NED group was higher than that in control group（P 〈 0.05 ）. The serum level of NO in DED group was significantly less than that in NED group and control group（P 〈0.01 ） ,the serum level of NO in NED group was significantly less than that in control group （P 〈 0.01 ）. Conclusions： Redox reaction play a promotion role in the development and occurrence of DED by the penile vascular endothelial injury mediated by NO.