促性腺激素释放激素激动剂治疗子宫内膜异位症45例

目的分析应用促性腺激素释放激素激动剂治疗子宫内膜异位症患者的临床疗效。方法选取医院2014年1月至2015年1月入院接受治疗的子宫内膜异位症患者90例，按入院顺序分为观察组和对照组，各45例。分析两组患者在接受不同治疗后的身体各项指标、疗效和不良反应情况。结果两组患者在治疗8周和16周时E2水平显著下降，但在月经恢复后有升至治疗前的水平，数据对比差异有统计学意义（P〈0．05）。观察组患者在用药后得骨密度值较用药前明显下降，但对照组用药前后骨密度值却无明显变化．两组数据对比差异有统计学意义（P〈0．05）。观察组实施不同治疗后总有效率为93．33％，明显优于对照组的88．89％（P〈0．05）。观察组患者在实施不同治疗后的不良反应率为26．66％，显著低于对照组的73.33％（／9〈0．05）。结论促性腺激素释放激素激动剂在治疗子宫内膜异位症方面较其他药物更安全有效，但使用后亦有不良反应，故使用的疗程不宜过长，最好控制在8～16周。

Objective To analyze the Ems patients with gonadotropin releasing hormone agonist therapy for adverse reactions. Methods Chosen the patients in our hospital from January,2014 to January,2015, hospitalization 90 Ems patients divided into two groups according to the order of admission,including the observation group （n=45） and the control group （n=45）.Comparative analysis of the two groups were the targets of the body after receiving different treatment, efficacy and adverse reactions. Results The two groups of patients in the treatment of eight weeks and 16 weeks E2 levels were significantly decreased, but in the period after the recovery has risen to the level before treatment, the difference was statistically significant data comparison （P 〈 0.05）. Observed before treatment compared with patients in bone mineral density was significantly decreased after treatment, but there was no detectable change in BMD in the control group before and after treatment, the two groups were statistically signifi- cant differences in data comparison （P 〈 0.05）. After the implementation of the different treatment groups were observed overall treatment effect and efficiency （93.33%） than the control group （88.88%）, compared to a statistically significant difference （P 〈 0.05）. Adverse reactions observed in patients rate （26.66%） to implement different after treatment was significantly lower than the control group （73.33%）, compared to a statistically significant difference （P 〈 0.05）. Conclusion Gonadotropin-releasing hormone agonists in the treatment of Ems than other aspects in terms of safer and more effective drugs, but after use also accompanied by various adverse reactions, medication use and therefore should not be too long, the best control in 8 to 16 weeks.