雷贝拉唑对消化性溃疡患者血液流变学及血小板聚集功能的影响

目的探讨雷贝拉唑对消化性溃疡患者血液流变学及血小板聚集功能的影响。方法选择208例消化性溃疡患者（胃溃疡患者162例，十二指肠溃疡患者46例），比较其服用雷贝拉唑治疗前和治疗6周后血液流变学参数及血小板凝集功能的变化。结果采用雷贝拉唑对消化性溃疡患者进行治疗后，胃溃疡患者和十二指肠患者的治疗总有效率分别达到88．27％和86．96％，其血液流变学参数均未有显著性变化（P〉0．05），而血小板聚集功能则有显著性提高（P〈O．05）。结论雷贝拉唑对消化性溃疡患者疗效良好，且对血小板聚集功能有显著改善，但对血液流变学未见明显影响。

Objective To explore the roles of rabeprazole on hemorheology and platelet aggregation in patients with peptic ulcer. Methods 208 patients with peptic ulcer（162 patients with gastric ulcer and 46 patients with duodenal ulcer） were collected and determine the change of the hemorheology indexes and platelet aggregation before treatment and after treatment in 6 weeks by Rabeprazole.Results The treatment efficiencies are 88.27% for the patients with gastric ulcer and 86.96% for the patients with duodenal ulcer. For the peptic ulcer, the level of hemorheology indexes did not be significantly decreased after treatment in 6 weeks （P 〉 0.05）,but the level of platelet aggregation was significantly increased after treatment in 6 weeks （P 〈 0.05）. Conclusion Rabeprazole has a good effect on patients with peptic ulcer, and has a significant improvement on platelet aggregation function,but has no significant effect on hemorheology.