氯吡格雷联合阿司匹林治疗急性缺血性脑卒中86例

目的观察氯吡格雷联合阿司匹林治疗急性缺血性脑卒中的疗效和安全性。方法选择急性缺血性脑卒中患者172例．随机分为治疗组和对照组，各86例，在常规治疗基础上，治疗组患者给予氯吡格雷联合阿司匹林肠溶片治疗，对照组患者给予阿司匹林治疗。比较两组患者治疗前后神经功能缺损评分（NDS）、临床疗效、出血事件和不良反应发生率。结果与阿司匹林组比较，氯吡格雷联合阿司匹林组可改善神经功能缺损（P〈0．05），临床疗效显著，也未增加出血事件和不良事件的发生率。结论氯吡格雷联合阿司匹林治疗急性缺血性脑卒中．可明显改善脑卒中患者的神经功能缺损．减轻致残程度．且安全性高．值得临床推广。

Objective Observation of clopidogrel to aspirin treatment of acute ischemic stroke efficacy and safety. Methods 172 cases of acute ischemic stroke patients were randomly divided into treatment group （86 cases） and control group（86 cases）,The two groups on the basis of conventional therapy, the treatment group received clopidogrel plus aspirin therapy, the control group was given aspirin therapy. Two groups of patients before and after treatment neurological deficit scores （NDS）, clinical efficacy, bleeding event rate and adverse reactions. Results Compared with aspirin, clopidogrel plus aspirin group can significantly improve neurological deficits （P 〈 0.05）, significant clinical effect, there is no increase in the incidence of bleeding events and adverse events. Conclusion Clopidogrel aspirin treatment of acute ischemic stroke, can significantly improve neurological function in patients with stroke defects, reduce the degree of disability, and safe.