比较新辅助放化疗与单纯手术治疗食管癌的临床效果

Comparison of the Clinical Effect Between Neoadjuvant Chemoradiotherapy and Surgery Alone in the Treatment of Oesophageal Cancer

目的对新辅助放化疗与单纯手术治疗食管癌的临床效果进行比较。方法随机选取该院2013年3月—2014年3月接收的50例食管癌患者为对象,根据治疗方式不同将患者分为观察组与对照组。观察组患者实施新辅助放化疗治疗方法,对照组实施单纯手术治疗方法,对两组患者的生存率、生活质量情况等进行比较。结果在近期疗效上,对照组与观察组的客观缓解率分别为40%与64%,观察组客观缓解率明显高于对照组(P<0.05)。在1年生存率上,观察组与对照组分别为96%、76%,观察组生存率明显高于对照组(P<0.05);在生活质量上,观察组术后1个月、3个月及1年后生活质量评分均显著高于对照组(P<0.05);在术后复发率上,观察组与对照组分别为8%与24%,观察组明显低于对照组(P<0.05)。在术后并发症发生率上,新辅助放化疗的并发症发生率为24%,单纯手术治疗的并发症发生率为28%,两组结果差异无统计学意义(P>0.05)。结论相比单纯手术治疗,新辅助放化疗治疗食管癌能够显著提升患者生存率,改善患者生活质量,降低患者术后并发率,值得临床推广应用。

Objective To compare the clinical effect between neoadjuvant chemoradiotherapy and surgery alone in the treatment of oesophageal cancer. Methods 50 patients with oesophageal cancer admitted in our department from March 2013 to March 2014 were divided into observation group and control group in accordance with the treatment method. Neoadjuvant chemoradiotherapy was given to the observation group, and surgery alone was given to the control group. The survival rate, quality of life and other indicators of the two groups was compared. Results In terms of short-term effects, the objective re- sponse rate of the observation group was much higher than that of the control group（64% vs 40%） （/）〈0.05）. The 1-year sur- vival rate of observation group was significantly higher than that of the control group（96% vs 76%） （P〈O.05）. The life quality scores of 1 month, 3 months, and 1 year after surgery in the observation group were all remarkably higher than those in the control group （/）〈0.05）. The postoperative recurrence rate was much lower in the observation group than that in the control group（8% vs 24%）（P〈0.05）. The incidence of postoperative complications was lower in the observation group than that in the control group （24% vs 28%）, but there was no marked difference between the two groups （P〉0.05）. Conclusion For oesophageal cancer, compared with surgery alone, neoadjuvant chemoradiotherapy can significantly increase the survival rate, improve the quality of life, and decrease the incidence of postoperative complications, which deserves further clinical application.