小剂量阿司匹林与氯吡格雷联合治疗缺血性脑血管病的疗效分析

Effect of Low-dose Aspirin Combined with Clopidogrel in the Treatment of Ischemic Cerebrovascular Disease

目的研究缺血性脑血管病行小剂量阿司匹林、氯吡格雷联用疗法的临床效果。方法从该院2012年5月—2014年10月接收患者中随机选取100例缺血性脑血管病对象进行调查,入院后分成不同疗法组(每组50例),即:研究组行小剂量阿司匹林、氯吡格雷疗法,对照组行阿司匹林疗法,临床预后分析疗效。结果研究组患者临床疾病治疗缓解率的94.0%明显高于对照组的78.0%,差异有统计学意义(P<0.05);研究组患者不良反应发生率6.0%和对照组8.0%差异无统计学意义(P>0.05)。结论临床针对缺血性脑血管病患者行小剂量阿司匹林、氯吡格雷联用疗法作用突出,不良反应轻微,值得应用。

Objective To study the clinical effect of low-dose aspirin combined with clopidogrel in the treatment of ischemic cerebrovascular disease. Methods An investigation was conducted in 100 selected patients with ischemic cerebrovaseular disease admitted in our hospital from May 2012 to October 2014. The patients were divided into the study group and the control group with 50 cases in each in accordance with the treatment given to them. The study group were treated by low-dose aspirin combined with elopidogrel, while the control group were treated by aspirin. And the clinical efficacy of the two groups was compared. Results The remission rate of the disease was much higher in the study group than that in the control group（94.0% vas 78.0%） with statistically significant difference （P〈0.05）. The difference in the incidence of adverse reactions between the study group and the control group was not significantly different（6.0% vs 8.0%） （P〉0.05）. Conclusion The clinical effect of low-dose aspirin and clopidogrel in patients with ischemic cerebral vascular disease is outstanding, and the adverse reactions are mild, so it is worthy of application.