新生儿高胆红素血症胱抑素C的临床分析

Clinical Analysis of Serum Cystatin C(CysC) in Hyperbilirubinemia of Newborn

目的探讨血清胱抑素C(Cys C)在新生儿高胆红素血症患儿中的临床应用,及其评估早期肾损伤的应用价值。方法选取2014年8月—2015年9月该院收治的90例新生儿高胆红素血症患儿为实验组,同期分娩的足月健康新生儿30例为对照组,进行血清总胆红素(TBIL)、胱抑素C(Cys C)、肌酐(Crea)和尿酸(UA)的检测。结果新生儿高胆红素血症患儿血清胱抑素C水平高于对照组,并与血清总胆红素水平呈正相关,而血清肌酐、尿酸与对照组比较差异无统计学意义,与血清总胆红素水平无相关性。结论血清胱抑素C可作为敏感指标,可应用于新生儿高胆红素血症患儿早期肾损害的评估,值得在临床上推广应用。

Objective To discuss the clinical application of serum cystatin C （CysC） in hyperbilirubinemia of newborn and evaluate the application value of early renal injury. Methods 90 cases of patients with hyperbilirubinemia of newborn treated in our hospital from August 2014 to September 2015 were selected as the experimental group, 30 cases of mature healthy newborns born at the same period were selected as the control group, the serum total bilirubin （TBIL）, cystatin C （CysC）, creatinine （Crea） and uric acid （UA） of the patients were detected. Results Serum cystatin C （CysC）level in the experimental group was higher than that in the control group, and was positively correlated with serum total bilirubin level, the difference in creatinine（Crea） and uric acid （UA） between the two groups were not statistically significant, and there was no correlation between creatinine （Crea） and uric acid （UA） and serum total bilirubin level. Conclusion Serum cystatin C （CysC） can used as a sensitive indicator in evaluating early renal injury in patients with hyperbilirubinemia of newborn, which is worthy of promotion and application in clinic.