褪黑素对老年轻度认识损害伴睡眠障碍患者高级脑功能及睡眠质量的影响

Effect of Melatonin on the Advanced Brain Function and Sleep Quality of Patients with Elderly Mild Cognitive Damage with Sleep Disorder

目的研究褪黑素对老年轻度认识损害(MCI)伴睡眠障碍患者高级脑功能及睡眠质量的影响。方法整群选取该院2012年8月—2014年8月收治的96例轻度认知损害伴睡眠障碍的老年患者,采用随机抽签法分为对照组和观察组,每组各48例。在日常护理治疗基础上,对照组采用安眠补脑口服液治疗,观察组采用褪黑素治疗,均持续治疗6个月。采用简易智力状况检查量表(MMSE)和匹兹堡睡眠质量指数量表(PSQI)观察两组脑认知功能和睡眠质量变化。结果观察组治疗后MMSE(28.1±1.6)分较对照组(25.8±2.1)分显著较高,PSQI(3.6±1.5)分较对照组(5.2±2.4)分明显较低,差异均具有统计学意义(P<0.05)。结论褪黑素能有效恢复老年轻度认知损害患者的脑认知功能,改善睡眠质量。

Objective To analyze the effect of melatonin on the advanced brain function and sleep quality of patients with elderly mild cognitive damage with sleep disorder. Methods 96 cases of elderly patients with mild cognitive damage with sleep disorder treated in our hospital from August 2012 to August 2014 were selected and randomly divided into two groups with 48 eases in each, the control group were treated with the sleeping brain oral liquid on the basis of daily nursing and treatment, the observation group were treated with melatonin on the same basis, both groups were treated for 6 months, the brain cognitive function and sleep quality changes of the two groups were observed by simple mental state examination scale （MMSE） and Pittsburgh sleep quality index scale （PSQI）. Results After treatment, the MMSE score in the observation group was obviously higher than that in the control group, （28.1±1.6）marks vs（25.8±2.1 ）marks, the PSQI score was obviously lower than that in the control group（3.6±1.5）marks vs（5.2±2.4）mark, the differences were statistically significant （P〈0.05）. Conclusion Melatonin can effectively recovery the brain cognitive function of the patients with elderly mild cognitive dam- age and improve the sleep quality.