伊曲康唑治疗老年慢性肺部疾病合并肺部真菌感染疗效分析

Analysis of Curative Effect of Itraconazole in Treatment of Elderly Chronic Lung Disease Combined with Pulmonary Fungal Infection

目的观察伊曲康唑治疗老年慢性肺部疾病合并肺部真菌感染的疗效。方法回顾分析2012年7月—2014年7月该科慢性肺部疾病合并肺部真菌感染51例。最初应用伊曲康唑注射液1~14 d,第1~2天,200 mg 1次/h,第3~14天,200 mg 1次/d,然后采用伊曲康唑胶囊序贯治疗,400 mg/d剂量水平,疗程2~4周。结果临床有效率86.2%。真菌清除率80.4%,不良反应发生率13.7%。结论使用广谱抗真菌药物-伊曲康唑疗法治疗老年慢性肺部疾病合并肺部真菌感染,疗效显著且安全,不良反应少,尤其适用于老年患者。

Objective To observe the curative effect of itraconazole in treatment of elderly chronic lung disease combined with pulmonary fungal ir/fection. Methods 51 cases of patients with chronic lung disease combined with pulmonary fungal infection treated in our department from July 2012 to July 2014 were retrospectively analyzed and they were injected with itraconazole for 1-14d, （1-2 days, 200mg once per hour, 3-14 days, 200rag once per day ） ,then they were given sequential therapy of itraconazole capsules, 400mg/d dose level and the course of treatment was 2-4 weeks. Results The effective rate in clinic was 86.2%, fungal elimination rate was 80.4% and the incidence of adverse reaction was 13.7%. Conclusion The application of broad-spectrum antifungal agents of itraconazole in treatment of elderly chronic lung disease combined with pulmonary fuugal infection has an obvious and safe curative effect and few adverse reactions, and especially suitable for el- derly patients.