肺癌靶向药物相关皮肤不良反应的中西医治疗进展

Western and Chinese Medicine Treatment Progress of Adverse Skin Reactions Associated with Lung Cancer Targeted Drugs

肺癌是目前世界上死亡率最高的恶性肿瘤,传统治疗方法包括手术、放疗和化疗,随着基因组学、分子生物学技术的发展,个体化靶向治疗应运而生。近年来,以表皮生长因子受体等为靶点的靶向药物研制取得重大进展,有些药物已经应用于临床并取得了满意的效果,但其临床不良反应也不容忽视。肺癌靶向药物中常见的不良反应是皮肤毒性,运用中医辨证结合西医治疗,患者相应皮肤不良反应的发生率可有效降低。故对近年来肺癌靶向药物相关皮肤不良反应进行归纳总结,探讨皮疹、皮肤干燥瘙痒、甲沟炎等皮肤不良反应的中西医治疗方法,旨在为临床提供参考。

The world＇s highest cancer mortality is lung cancer, traditional treatments for lung cancer include surgery, radiotherapy and chemotherapy. With the development of genomics, molecular biology techniques, individualized targeted therapy emerged, in recent years, the epidermal growth factor receptors as a target for drug development targeting significant progress, some drugs have been used in clinical and achieved satisfactory results. But their clinical adverse reactions can not be ignored. The most common adverse reactions in targeted drug therapy are skin toxicity. In this paper, many of the targeted drugs induced skin reactions were summarized. Discussion the therapy of lung cancer targeted drug adverse reaction from the rash, dry skin itching, paronychia and many skin reactions. Use of traditional Chinese medicine syndrome differentiation, combined with Western medicine treatment, the incidence of adverse reactions in patients with the skin can effectively reduce. This article is intended to provide a reference for the actual work of domestic clinical medicine personnel to develop good treatment options and reduce skin reactions targeted drugs.