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曲洛司坦有关物质的合成

Synthesis of the Related Substances of Trilostane
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摘要 根据曲洛司坦的结构及合成工艺,制备了可能存在的3个有关物质:17?-羟基-4?,5?-环氧雄甾烷并[3,2-c]异噁唑(A)、2-氰基雄甾-2,4-二烯-3,17?-二醇(B)和4?,5?-环氧-2?-氰基-17?-羟基雄甾-3-酮(C),并经MS、1H NMR和13C NMR确证结构,以作为曲洛司坦质量研究的参照物。 According to trilostane structure and its synthetic process, three related substances： 17β-hydroxy- 4α,5α-epoxy-androst-2-eno [3,2-c] isoxzole （A）, 3,17β-dihydroxy-androst-2,4-diene-2-carbonitrile （B） and 4β,5β-epoxy- 17β-hydroxy-3-oxo-androst-2β-carbonitrile （C） were prepared and confirmed by MS, ^1H NMR and ^13C NMR. These substances were taken as the references for the quality control of trilostane.
作者 李永 朱桃 樊玲玲 王建塔 汤磊
机构地区 贵州医科大学药学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2016年第3期273-276,共4页 Chinese Journal of Pharmaceuticals
基金 贵州省高等学校药物化学工程研究中心项目(黔教合KY字[2014]219)
关键词 曲洛司坦 库欣综合征 原发性醛固酮增多症 抗雌激素药 有关物质 合成 trilostane Cushing syndrome primary aldosteronism antiestrogen agent related substance synthesis
分类号 R979.9 [医药卫生—药品]
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参考文献10

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二级参考文献9

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中国医药工业杂志
2016年 第3期

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