脑卒中后抑郁程度与脑源性神经营养因子水平的相关性研究

Post-stroke depression level and the level of brain derived neurotrophic factor correlation studies

目的通过观察脑卒中后患者汉密顿抑郁量表(HAMD)及血清脑源性神经营养因子(BDNF)水平,探讨脑卒中后抑郁(PSD)程度与BDNF水平的相关性。方法选取脑卒中患者380例作为研究对象,采用HAMD进行评分及分组,同时采用ELISA法检测血清BDNF水平,进行统计学分析。结果 380例脑卒中患者抑郁症状的发病率为44.5%(169/380)。有抑郁症状组与无抑郁症状组比较,HAMD分值差异具有统计学意义(t=9.711,P<0.01),血清BDNF水平差异具有统计学意义(t=3.709,P<0.01)。脑卒中患者HAMD分值与血清BDNF水平呈显著负相关性(r=-0.514,P<0.01)。结论脑卒中后抑郁症状的发病率高,其抑郁程度与BDNF水平负相关;血清BDNF水平可作为判定脑卒中患者抑郁程度及抗抑郁疗效的参考指标。

Objectives By observing the patients after stroke HAMD and serum brain derived neurotrophic factor （BDNF） levels, investigate the relationship between level of post-stroke depression（PSD） and BDNF levels. Methods Select 380 cases of patients with cerebral apoplexy as the research object, using HAMD scores and grouping, using ELISA method to detect serum BDNF levels at the same time, the statistical analysis. Results The incidence of 380 cases of depressive symptoms in patients with cerebral apoplexy was 44. 5% （169/380）. Depressive symptoms group compared with no depression symptoms group, HAMD score differences statistically significant （ t = 9. 711, P 〈 0. 01 ）, serum BDNF level statistically significant difference （ t = 3. 709, P 〈 0. 01 ）. Stroke patients with HAMD score and serum BDNF levels were significantly negative correlation（ r = -0. 514 ,P 〈 0. 01 ）. Conclu- sions The high incidence of depression after stroke, the degree of depression is negatively related to the level of BDNF. Serum BDNF levels can be used as the degree of depression in patients with cerebral apoplexy and the antidepressant effect of reference index.