帕瑞昔布钠超前镇痛联合罗通定围手术期镇痛的疗效

Curative effect observation of elderly Total Hip Arthroplasty Perioperative of Parecoxib Sodium Preemptive Analgesia with Rotundine

目的研究观察帕瑞昔布钠超前镇痛联合罗通定对老年全髋关节置换术围手术期镇痛的疗效。方法选取70例老年全髋关节置换术患者,随机分为试验组和对照组,试验组在切皮前30分钟以及术后第1天、第2天静脉滴注帕瑞昔布钠40mg,每12小时1次,并在术后第1天开始口服罗通定片60mg,3次/日。对照组在与试验组应用帕瑞昔布钠相同时间点给予盐酸曲马多片100mg,每12小时1次。记录患者术后疼痛评分、关节功能恢复情况、检测围手术期体温、白细胞总数、超敏C反应蛋白及围手术期血清白介素-6水平。结果在静息疼痛和活动疼痛方面,试验组在术后所有考察的时间点VAS评分均低于对照组(P<0.05),试验组术后各时间点体温、白细胞总数、超敏C反应蛋白和白介素-6水平均低于对照组(P<0.05),在直腿抬高、下地活动和出院天数方面,两组差异无统计学意义(P>0.05)。结论帕瑞昔布钠超前镇痛联合罗通定对老年全髋关节置换术围手术期镇痛的疗效显著,并具有降低术后炎症应激水平的作用。

Objectives To discuss the curative effect of elderly total hip arthroplasty perioperative of parecoxib sodium preemptive analgesia with rotundine. Methods Selected 70 cases of elderly patients with total hip arthroplasty, randomly divided into experimental group and control group, The experimental group intravenoued parecoxib sodium 40mg on 30min before the incision and the first and second days after surgery,ql2h. And the first day after surgery oraled rotundine 60mg,tid. The control group gived tramadol hydrochloride lO0mg in the same time of parecoxib sodium, ql2h. The patients ＇ postoperative pain score ,joint function recovery were recorded, and the perioperative body temperature, total number of white blood cells, hypersensitive c-reactive protein and perio- perative serum level of interleukin -6 were detected. Results The VAS of the patients in the experimental group at the stages were lower than those in the control group （P 〈 O. 05 ）. The postoperative Patients＇ temperature at each time point, total number of WBC, hypersensitive c-reactive protein and interleukin-6 levels were lower than those in the control group （ P 〈 0. 05 ） ; In the straight leg- raising above or on Ambulation and the days of discharged, the differences between the two groups had no statistical significance （ P 〉 0. 05）. Conclusions The effection is significant about elderly total hip arthroplasty perioperative of parecoxib sodium preemptive analgesia with rotundine, and stress levels have reduced of the role of postoperative inflammation.