高脂饮食促进结直肠癌发生机制的研究进展

Research Progress of the Mechanisms of High Fat Diet Induced Colorectal Cancer

结直肠癌(colorectal cancer,CRC)是消化道常见肿瘤之一,在我国已成为发病率居第三位的恶性肿瘤。CRC病因复杂,主要包括遗传背景和环境因素,而后者与生活方式关系密切。高脂饮食通过影响胆汁酸代谢,改变肠道通透性、固有免疫及肠道菌群,进而诱发低度炎症等,增加了CRC的发病风险并促进了CRC的发生发展。本文就近年来对高脂饮食促进CRC的分子机制研究进行综述。

Colorectal cancer （CRC） is one of the most common gastrointestinal tumors. It has been the third most frequently diagnosed cancer in China. Yet, the etiology of CRC is complex, including genetics and environmental factors, and the latter aspect is significantly as- sociated with the fast pace western life style. High fat diet increases the risk of CRC in many ways, including influencing bile acid metabo- lism, changing intestinal permeability, innate immunity and gut mierobiota, as well as inducing low grade inflammation. In this article, we summarized the recent advances in the mechanisms of how high fat diet nromotes CRC.