PD-1、PD-L1蛋白在外周T细胞淋巴瘤中的表达及其与预后的关系

The PD-1 and PD-L1 Protein Expression in Peripheral T cell Lymphoma and Their Correlation with Prognosis

目的探讨外周T细胞淋巴瘤(peripheral T cell lymphoma,PTCL)患者肿瘤组织中程序性细胞死亡受体1(programmed cell death-1,PD-1)和程序性细胞死亡受体1配体(programmed death ligand 1,PD-L1)蛋白的表达情况,分析其与患者预后的关系。方法采用免疫组化法检测PTCL患者肿瘤组织中PD-1、PD-L1蛋白的表达,并分析其表达与患者临床分期、疗效及预后之间的关系。结果 PTCL患者肿瘤组织中PD-1蛋白的表达阳性率为35%,PD-L1蛋白的阳性率为70%,炎性淋巴结组织中未见PD-1、PD-L1表达,PD-1、PD-L1蛋白的表达与患者临床分期正相关,PD-1蛋白的表达与疗效负相关,PD-1与PD-L1蛋白双阳性的PTCL患者生存期明显缩短。结论PTCL患者淋巴瘤组织中PD-1和PD-L1蛋白表达阳性率高于炎性淋巴结组织,是预后不良的指标。

Objective To investigate the protein expression of programmed cell death-1 （PD-1） and programmed death ligand 1 （PD-L1） in the tissues of peripheral T-cell lymphoma （PTCL）, and to analyze the relationship between its expression, chemotherapeu- tic effect and prognosis. Methods The expressions of PD-1 and PD-L1 protein in tumor tissue of PTCL were detected by immunohis toehemistry. The correlation between the protein expressions, clinical stages and prognosis was evaluated. Results In tumor tissues of PTCL patients, the expression rate of PD-1 protein was 35%, while the expression rate of PD-L1 was 70%. In the normal inflamma- tory lymph nodes, the expression of PD-L1 and PD-1 were not found. The expressions of PD-1 and PD-L1 were positively correlated with clinical stages. The expression of PD-1 was negatively correlated with curative effect. Survival rate was signi/icantly lower in the patients with PD-L1 and PD-1 co-expression. Conclusion The expression rates of PD-1 and PD-L1 protein in lymphoma tissues of PTCL patients were higher than in normal inflammatory lymph nodes, and they may be the potential indicators of poor prognosis.