MMP-7在非小细胞肺癌中的研究进展

Research progress of MMP -7 in non - small lung cancer

肺癌是当今世界最常见的恶性肿瘤之一，其中约85％为非小细胞肺癌，发病机制至今尚不明确。基质金属蛋白酶（MMPs）是一组能降解细胞外基质和基底膜的蛋白溶解酶家族，各成员具有相似的结构及一定的底物特异性。有研究显示基质金属蛋白酶家族中的基质金属蛋白酶7（MMP-7）参与了非小细胞肺癌的浸润和转移，在非小细胞肺癌组织中MMP-7的表达明显高于癌旁组织，且MMP-7对非小细胞肺癌患者的预后评估亦有重要意义。因此，本文就MMP-7结构、功能、表达的调节等几个方面进行综述。

Lung cancer is one of the most common malignant tumors in the world. Non - small lung canc- er（NSCLC） accounts for approximately 85% ,but its pathogenesis has not been elucidated. As a family of soluble enzymes, matrix metalloproteinases （MMPs） can degrade the constituents of the extracellular matrix （ECM） and the basement - membrane, members share common structural features and are responsible for the relative specific sub- strates. Some researches show that the matrix metalloproteinases 7 （ MMP - 7 ） involve in the invasion and metasta- sis of NSCLC, the expression of MMP -7 in the tissue of NSCLC is significcantly higher than that in adjacent tis- sues, and the MMP - 7 plays important roles in prognosis evaluation of NSCLC patients. Therefore this paper sum- marize the domain structure,function, regulation and research in NSCLC about MMP- 7.