期刊文献+

棕色脂肪组织分化及调控的研究进展 被引量:10

下载PDF
导出
摘要 棕色脂肪组织是哺乳类动物存在的另一种特殊类型的脂肪,通过线粒体氧化呼吸链解偶联作用,释放热能。近年研究发现,儿童时期乃至成人中仍存在代谢活跃的棕色脂肪。本文总结了棕色脂肪组织分化、组织结构、生理功能及其调节机制的研究进展,以阐明棕色脂肪组织在能量代谢中的作用和机制,从而为肥胖及其相关疾病的防治提供新的途径。
作者 陈冉 李晓南
出处 《生理科学进展》 CAS CSCD 北大核心 2016年第1期38-42,共5页 Progress in Physiological Sciences
  • 相关文献

参考文献20

  • 1World Health Organization. 2014. 10 facts on obesity, World Health Organ. http://www. who. intlfeautres/factiles/obesity/en/.
  • 2Dinas PC, Nikaki A, Jamurtas AZ, et al. Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET -CT scan. Clin Endocrinol (Oxf) ,2015,82 : 147 -154.
  • 3Kajimura S, Saito M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol,2014,76 : 225 -249.
  • 4Villarroya F, Giralt M. The beneficial effects of brown fat transplantation: further evidence of an endocrine role of brown adipose tissue. Endocrinology, 2015 , 156 : 2368 - 2370.
  • 5Villarroya J, Cereijo R, Villarroya F. An endocrine role for brown adipose tissue? Am J Physiol Endocrinol Metab,2013, 305 : E567 - E572.
  • 6Harms MJ, Ishibashi J, Wang W , et al. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab,2014,19 : 593 -604.
  • 7Harms MJ, Lim HW, Ho Y, et al. PRDM16 binds MEDl and controls chromatin architecture to determine a brown fat transcriptional program. Genes & development, 2015 , 29 : 298 - 307.
  • 8Cohen P, Levy 10, Zhang Y, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell,2014, 156 : 304 - 316.
  • 9Betz MJ, Bielohuby M, Mauracher B, et al. Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats. PLoS One,2012,7 : e38997.
  • 10Vosselman MJ, Brans B, van der Lans AAJJ, et al. Brown adipose tissue activity after a high-calorie meal in humans. Am J Clin Nutr,2013,98 : 57 -64.

同被引文献60

引证文献10

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部