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熊去氧胆酸联合中药治疗原发性胆汁性肝硬化疗效观察 被引量:12

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摘要 原发性胆汁性肝硬化,现更名为原发性硬化性胆管炎(PBC)是一种主要累及肝内细小胆管的慢性非化脓性的自身免疫性肝病,逐步发展为汇管内炎症、慢性胆汁瘀积、肝纤维化,最终可演变为肝硬化和肝功能衰竭,多发于中年妇女,近年来我国发现PBC患者日益增多^([1]),PBC在人群中发病率为每年4~30例/百万,死亡占肝硬化死亡总数的1.6%~2%^([2,3])。该病的发病机制尚未完全明了,治疗上也缺乏特异手段,是临床治疗的一大难题^([4])。笔者采用熊去氧胆酸联合中药治疗PBC,
出处 《中西医结合肝病杂志》 CAS 2016年第1期52-54,共3页 Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
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  • 1[1]Beuers U, Boyer JL, Paumgartner G. Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic application[J]. Hepatology, 1998, 28:1449-1453.
  • 2[2]Paumgartner G. Ursodeoxycholic acid treatment of primary biliary cirrhosis: potential mechanisms of action [ M ]. In: LindorKD,Heathcote Ej, Poupon R, eds. Primary Biliary Cirrhosis: From Pathogenesis to Clinical Treatment. Dordrecht: Kluwer Academic Publishers, 1998.138 - 146.
  • 3[3]Tanaka M, Nakura H, Tateishi T, et al. Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid- induced liver injury[J]. J Hepatol, 1999, 31 (2):263 - 270.
  • 4[4]Rodrigues CM, Fan G, Ma X, et al. A novel role for ursodeoxycholic acid in inhibiting mitochondrial membrane perturbation[J]. J Clin Invest, 1998, 101:2790- 2799.
  • 5[5]Angulo P, Lindor KD. Managent of primary biliary cirrhosis and antoimmune cholangitis[J]. Clin Liver Dis, 1998, 2:333 - 351.
  • 6[6]Combes B, Carithers RL Jr, Maddrey WC, et al. Biliary bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid[J]. Hepatology, 1999, 29(6): 1649 - 1654.
  • 7[7]Degott C, Zafrani ES, Callard P, et al. Histopathological study of primary biliary cirrhosis and the effect of ursodeoxycholic acid treatment on histology progression[J]. Hepatology, 1999, 29(4):1007- 1012.
  • 8[8]Angulo P, Batts KP, Therneau TM, et al. Long term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis [J]. Hepatology, 1999, 29(3):644-647.
  • 9[9]Pasha T, Heathcote J, Gabriel S, et al. Cost effectiveness of ursodeoxycholic acidtherapyinprimary biliary cirrhosis[J].Hepatology,1999,29(1):21-26.
  • 10[10]Lindor KD.Ursodial for primary sclerosingcholangitis.Mayo Primary Sclerosing Cholangitis-Ursodeoxycholic Acid Study Group[J].NEJM,1997,336:691-695.

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