HBeAg慢性乙肝患者病毒活动力与肝脏储备功能相关性分析

Correlation Analysis between Viral Motility and Hepatic Functional Reserve of Chronic Hepatitis B Patients,HBeAg

目的分析不同Child-Pugh分级HBe Ag阴性慢性乙肝患者病毒活动能力的差异,探讨肝脏储备功能与乙肝病毒活动力的相关性。方法收集慢性乙肝患者597例,按照Child-Pugh分级分组,比较各组中病毒复制能力反应指标HBV免疫标志物和HBV-DNA的差异,分析病毒复制能力与肝脏储备功能的相关性。结果 HBe Ag阴性慢性乙肝患者按照Child-Pugh分级发现,不同分级的患者HBV-DNA表达水平差异有统计学意义(P<0.05),相关性调查发现病毒复制水平与Child-Pugh分级呈现明显负相关(r=-0.49,P=0.00)。HBe Ag阴性慢性乙肝不同Child-Pugh分级的患者免疫血清标志物表现明显不同,差异有统计学意义(P<0.05);进一步对不同标志物分析发现,Hbs Ag和anti-HBs表达与Child-Pugh分级评分存在相关性。结论 HBe Ag阴性慢性乙肝患者病毒活动力与患者肝脏储备功能存在相关性,这种相关性的发现有利于乙肝患者病程发展中的药物有效性以及机体耐受力的全面评估,以便乙肝患者的抗病毒治疗正确方案的确定提供可靠的实验室检测数据。

Objective To analyze the differences of viral motility among diverse HBeAg negative chronic hepatitis B pa- tients with different Child-Pugh classifications and discuss the correlation between hepatic functional reserve and the motility of hepatitis B virus. Methods 597 cases of chronic hepatitis B patients were collected and defined into different groups according to child-pugh grades. The differences between HBV immune markers and HBV-DNA which could be looked as reaction indexes reflec- ting the ability of viral replication were compared so as to analyze the correlation between the ability of viral replication and hepatic functional reserve. Results There was statistically significant difference in the expression level of HBV-DNA among HBeAg nega- tive chronic hepatitis B patients with different Child-Pugh classifications （ P 〈 0. 05 ）. Correlation investigation found that there was a significantly negative correlation between viral replication level and Child-Pugh classification （r = -0. 49, P = 0. 00）. The serous immune markers of HBeAg negative chronic hepatitis B patients with different Child-Pugh classifications showed a significant differ- ence,there was statistically significant difference （P 〈 0. 05 ）. Further Analysis of different markers showed that HbsAg and the ex- pression Of Anti-HBs both had correlations with the score of Child-Pugh classification. Conclusion There was correlation be- tween the motility of hepatitis B virus and the hepatic functional reserve of HBeAg negative chronic hepatitis B patients. And the discovery of the correlation was advantageous for us to give a comprehensive assessment in the trug availability and body enduranc, e during the disease development of hepatitis B patients,in order to provide reliable laboratory test data to determine a right plan of antiviral treatment for patients with hepatitis B.