肾癌与维生素D相关性研究进展

Research progress of the correlation between vitamin D and kidney cancer

近年来,维生素D相关的研究迅速开展,维生素D在血钙调节、维持骨骼稳态方面起着重要的作用,较多研究发现维生素D对多种肿瘤都有抑制作用,近年流行病学研究也发现充足的维生素D可能抑制肾癌的发生及发展,目前主要机制可能是通过抑制肿瘤增殖、分化、抗肿瘤血管生成、促进凋亡、免疫调节等途径抑制肾细胞癌,这也为预防和治疗肾癌的新方法。本文就肾癌与维生素D、维生素D结合蛋白以及维生素D受体的研究进展予以综述。

Scientific researches of vitamin D have been greatly developed recently. Vitamin D plays an important role in regulating blood calcium and maintaining bone homeostasis. Recent studies have found that vitamin D has inhibitory effect on tumors. The current epidemiological studies have found that sufficient vitamin D can suppress the occurrence and development of kidney cancer, which will be the new direction for the prevention and treatment of kidney cancer. The mechanism may be that vitamin D can prevent kidney cancer through proliferation, differentiation inhibition, anti-angiogenesis, apoptosis promotion and immune regulation. Here is to make a review of the relatinnship of kidney cancer with VD, VDBP and VD receptor.