摘要
目的探讨冠心宁注射液治疗冠心病的疗效及作用机制。方法选取我院2012年1月~2015年1月收治入院的冠心病患者200例作为研究对象,随机分为观察组和对照组,两组均按心血管指南行常规强化治疗,给予抗血小板聚集、β-肾上腺素能受体阻滞剂(简称β-阻滞剂)、硝酸脂类、血管紧张素转换酶抑制剂(ACEI)等药物口服。观察组除常规治疗外加用5%葡萄糖或生理盐水500m L加入冠心宁注射液20m L静脉滴注,1次/d,连续14d;治疗前后分别记录临床效果、心功能、血流变等指标。结果观察组患者临床总有效率明显高于对照组,差异有统计学意义(P〈0.05);观察组患者治疗后EF、SV、IVS、RPP等心功能指标明显优于治疗前和对照组治疗后,差异均有统计学意义(P〈0.05)。观察组患者治疗后全血高切黏度、全血低切黏度、红细胞压积、血浆黏度、纤维蛋白等血流变指标均明显优于治疗前和对照组,且比较差异有统计学意义(P〈0.05)。两组患者均未见明显全身不良反应。观察组中4例出现烦躁、头晕、出汗等不适症状,2例出现注射位瘀血。结论冠心宁注射液应用治疗冠心病的治疗效果显著,能显著改善冠脉血流增加心肌供血,调节血脂及凝血系统,改善微循环。是一种安全有效的治疗措施,且价格实惠,值得临床推广应用。
Objective To investigate the curative effect and mechanism of Guanxinning injection in the treatment of coronary heart disease. Methods 200 patients with coronary heart disease who were admitted to our hospital from January 2012 to January were selected and randomly divided into observation group and control group.The two groups were received by routine intensive treatment according to guidelines for cardiovascular diseases. And they were received oral administration of anti-platelet aggregation, beta adrenergic receptor blocker (beta blockers),nitric acid,angiotensin converting enzyme inhibitor (ACEI) and other drugs.The observation group was received intravenous drip of 500ml of 5% glucose or normal saline plus 20mL of Guanxinning injection once a day for 14 days at the basis of the routine treatment.Clinical curative effect, heart function,blood flow change and other indexes before and after treatment were recorded. Results The total clinical effective rate of the observation group was significantly higher than that of the control group and the difference had statistical significance (P 〈 0.05).New function indexes including EF,SV,IVS,RPP after treatment of patients in the observation group were superior to those before treatment.After treatment, differences in new function indexes including EF,SV,IVS,RPP of two groups had statistical significance (P 〈 0.05).Whole blood high shear viscosity,whole bloodlow shear viscosity, hematocrit, plasma viscosity, fibrae sanguis and other blood rheological indexes after treatment of the observation group were significantly better than those before treatment and the control group (P 〈 O.05).There was no obvious adverse reaction in the two groups.In the observation group,there were d cases of irritability,dizziness,sweating and other discomfort symptoms and 2 cases of blood congestion injections. Conclusion The curative of Guanxinning injection in treating coronary heart disease was significant.It can significantly improve the coronary blood flow,increase myocardial blood supply,regulate blood lipid and blood coagulation system and improve microcirculation. It is a safe and effective treatment with low costs,worthy of clinical promotion and application.
出处
《中国医药科学》
2016年第2期44-46,90,共4页
China Medicine And Pharmacy
关键词
冠心病
冠心宁注射液
心绞痛
心电图
血脂
Coronary heart disease
Guanxinning Injection
Angina pectoris
Electrocardiogram
Blood lipid