双歧三联活菌片联合蒙脱石散治疗小儿腹泻的临床疗效对比分析

Comparative analysis of clinical curative effect of bifid triple viable bacterial tablets combined with montmorillonite powder in treatment of infantile diarrhea

目的探讨双歧三联活菌片联合蒙脱石散治疗小儿腹泻的临床价值,指导小儿腹泻的临床治疗用药方案。方法选取我院2011年1月~2015年8月收治的小儿腹泻患儿共60例,所有患儿均按照入院时间顺序随机数表法分为对照组与观察组,两组患儿均接受小儿腹泻常规治疗包括补液、维持水电解质平衡,抗感染等。对照组患儿接受口服蒙脱石散治疗,观察组患儿接受口服双歧三联活菌片联合蒙脱石散。治疗结束后比较两组患儿小儿腹泻治疗总有效率,腹泻相关症状及各项指标恢复时间。结果观察组患儿小儿腹泻治疗总有效率为93.7%,明显高于对照组患儿腹泻治疗总有效率73.3%,差异有统计学意义（P〈0.05）。观察组患儿腹泻相关症状及各项指标如大便性状恢复正常时间、退热时间、便常规各项指标恢复正常时间、呕吐消失时间、腹痛缓解时间均明显短于对照组患儿,差异有统计学意义（P〈0.05）。结论口服双歧三联活菌片与蒙脱石散对治疗小儿腹泻有较好的效果,临床效果优于单独口服蒙脱石散,且安全,无明显不良反应发生,值得临床推广运用。

Objective To explore the clinical value of bifid triple viable bacteria tablets combined with montmorillonite powder in the treatment of infantile diarrhea to guide clinical treatment scheme of infantile diarrhea. Methods 60 children with infantile diarrhea who were admitted to our hospital from January 2011 to August 2015 were selected and they were divided into the control group and observation group according to the order of admission time by random number table method. Children in two groups were all received routine treatment including fluid infusion, maintenance of water electrolyte balance, anti-infection, etc. Children in the control group were treated with oral montmorillonite powder while patients in the observation group were treated with bifid triple viable bacteria tablets combined with montmorillonite powder. After treatment, the total effective rate, recovery time of symptoms related to infantile diarrhea and every index in two groups were compared. Results The total effective rate of children with infantile diarrhea in the observation group was 93.7%, significantly higher than that of the control group 73.3%. The difference was statistically signifieant（P 〈 0.05）. Recovery time of symptoms related to infantile diarrhea and every index including feces returned to normal time, cooling time, every feces routine index returned to normal time, vomiting disappearance time and abdominal pain relief time were all significantly shorter than those of patients in the control group. The difference was statistically significant（P 〈 0.05）. Conclusion Bifid triple viable bacterial tablets combined with montmorillonite powder in treatment of infantile diarrhea have good effect. And the clinical effect is better than the single oral montmorillonite powder. In addition, it is safe and has no adverse reactions, worth of clinical promotion and application.