羟基铬处理的牛心包片及涤纶片在先天性室间隔缺损修补术中的应用比较研究

The comparison between bovine pericardium and Dacron hydroxy chrome on the congenital ventricular septal defect surgery

目的 比较采用羟基铬处理的牛心包片与涤纶片进行先天性室间隔缺损修补术的临床价值及实用性。方法 选取2013-04~2014-04该院收治的先天性窒间隔缺损患者50例,以2013-04~2013-12就诊的25例为牛心包组,2014-01~2014-04就诊的25例为涤纶组。牛心包组将提前准备好的2~3岁的牛心包应用戊二醛进行固定制备后,采用手术方法对相应的缺损进行修补。涤纶组采用涤纶片修补术进行修补。对术后患者进行1~3年随访。结果 50例患者中大部分在手术治疗后生命体征稳定,精神状态良好,症状基本消失,无发热、咳嗽、消化道症状等并发症发生。牛心包组的不良反应发生率为12.0%,涤纶组的不良反应发生率为40.0%,两组比较差异具有统计学意义（P〈0.05）。结论 羟基铬处理的牛心包片对先天性室间隔修补较涤纶片效果好,并发症较少。

Objective To compare the clinical application value between hydroxyl chromium bovine package film and polyester film in the treatment of congenital ventrictdar septal defect（VSD）. Methods A total of 50 cases with congenital heart disease were enrolled from April 2013 to April 2014 in our hospital and were divided into two groups ： bovine package group （ n = 25 ） and polyester group（ n = 25 ）. The bovine pericardium group received the repair surgery with glutaraldehyde-fixed bovine pericardium path. The polyester group received the repair surgery with terylene. All the patients were followed up for 1 to 3 years, the clinical results were analyzed and compared between the two groups. Results After the treatment, life signs of the 50 patients were stable. All the symptoms including fever, cough and gastrointestinal symptoms were disappeared. The incidences of adverse reactions respectively were 12.0% and 40. 0% in the bovine package group and in the polyester group, with a significant difference（ P 〈 0. 05 ）. Conclusion The hydroxyl chromium bovine pericardium patch has a better clinical effect and less complications on repairing congenital ventricular septal defect than polyester film.