上颌窦黏液纤毛传输途径动物模型的实验探讨

An experimental animal model of maxillary mucocilliary transport pathway

目的探讨建立兔上颌窦黏液纤毛传输途径模型的方法和可行性。方法以10只大白兔20侧上颌窦为研究对象,局麻下开放上颌窦前壁骨窗,大1 cm×0.8 cm,用鼻内窥镜观察亚甲蓝在上颌窦窦腔内的传输途径,时间为1.5 h。结果局麻下能顺利实验,1 cm×0.8 cm大的上颌窦前壁骨窗能够满足实验操作需要。亚甲蓝在兔上颌窦窦腔内由底壁向上颌窦自然开口的前下缘方向传输,并经该部传到鼻腔。结论可以利用兔上颌窦代替人上颌窦进行与黏液纤毛传输系统相关的实验研究。

Objective To explore the feasibility of establishing an experimental rabbit model of mucociliary transport system of maxillary sinus. Methods Twenty maxillary sinuses of 10 rabbits were included in this research. Local anaesthesia was performed. The size of bone window at the anterior wall of maxillary sinus was 1 cm × 0. 8 cm. Transport pathway of methyhhioninium chloride was observed by trasnasal endonasal endoscope for 1.5 hour. Results All experiments were smoothly finished under the local anaesthesia. The bone window size of 1 cmx 0. 8 em could be satisfactory for all experimental manipulations. Methylthionlnium chloride was transported from inferior wall to anterior-inferior edge of the maxillary natural ostium directly, and then transported out of maxillary sinus at that site. Conelusion White rabbits can be established to be experimental model of the research related to maxillary mueociliary transport system.